diphencyprone
Small moleculeexperimental
Diphenylcyclopropenone (diphencyprone) is a topically administered experimental drug intended for treating alopecia areata and alopecia totalis. Topical immunotherapy using diphenylcyclopropenone may also be an effective treatment option for recalcitrant warts. It is not approved by either the Food and Drug Administration or the European Medicines Agency. — Wikipedia
Clinical trial activity
8 trials · 8 clinical orgs · 0 marketing orgs
Phase 1
4
Phase 2
2
Phase 3
1
Phase 4
1
Earliest trial started Oct 1, 2012 (NCT01711684)
Timeline
Indications
Approved for
Mechanism of action
- UnclearUnclear
Unclear unclear
Chemistry & pharmacology
Loading structure…
SMILES
O=c1c(-c2ccccc2)c1-c1ccccc1- Mol. weight
- 206.24 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaDiphenylcyclopropenone ↗
- ChEMBLCHEMBL1373467 ↗
Also known as
- 2,3-diphenyl-2-cyclopropen-1-one
- diphencyprone
- diphencyprone
- diphencyprone
- diphenylcyclopropenone
- diphenylcyclopropenone
- diphenylcyclopropenone
- diphenylcyclopropenone
- diphenylcyclopropenone monohydrate
- dpcp
- dpcp
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05481658 | Phase 1 | Oct 6, 2022 | Icahn School of Medicine at Mount Sinai |
| NCT05438290 | Phase 1 | Sep 30, 2022 | Icahn School of Medicine at Mount Sinai |
| NCT05020496 | N/A | Jan 1, 2022 | University of Alabama, Birmingham |
| NCT04775979 | Phase 4 | Jan 17, 2021 | Ain Shams University |
| NCT03651752 | Phase 3 | Sep 1, 2018 | National Alopecia Areata Foundation, University of Minnesota |
| NCT02640820 | Phase 2 | Dec 1, 2015 | RXi Pharmaceuticals |
| NCT01978483 | Phase 1 | Nov 1, 2013 | Innovaderm |
| NCT01711684 | Phase 1 | Oct 1, 2012 | Rockefeller University |
Showing 8 of 8 trials
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Organizations
Research & Development (8)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Icahn School of Medicine at Mount Sinai | Academic/Hospital | 2 | 2 | 1 | 2022 |
| Ain Shams University | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Innovaderm | For profit | 1 | 1 | 1 | 2013 |
| National Alopecia Areata Foundation | Academic/Hospital | 1 | 0 | 1 | 2018 |
| Rockefeller University | Academic/Hospital | 1 | 1 | 1 | 2012 |
| RXi Pharmaceuticals | For profit | 1 | 1 | 1 | 2015 |
| University of Alabama, Birmingham | Academic/Hospital | 1 | 1 | 1 | 2022 |
| University of Minnesota | Academic/Hospital | 1 | 1 | 1 | 2018 |
8 organizations
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