tigilanol tiglate
Small moleculeexperimental
Clinical trial activity
4 trials · 6 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
4
Phase 3
0
Phase 4
0
Earliest trial started May 7, 2021 (NCT04834973)
Timeline
Indications
Mechanism of action
- Protein kinase C (PKC)ACTIVATOR
Protein kinase C (PKC) activator
Approved veterinary
- Serine/threonine-protein kinase (PRKD3) ↗
- Serine/threonine-protein kinase (PRKD1) ↗
- Protein kinase C zeta (PRKCZ) ↗
- Protein kinase C (PRKCQ) ↗
- Protein kinase C iota type (PRKCI) ↗
- Protein kinase C (PRKCG) ↗
- Protein kinase C eta type (A0A8I3PGY9) ↗
- Protein kinase C epsilon type (PRKCE) ↗
- Protein kinase C delta type (PRKCD) ↗
- Protein kinase C (PRKCA) ↗
- PRKCA-binding protein (PICK1) ↗
Chemistry & pharmacology
Loading structure…
SMILES
C/C=C(\C)C(=O)O[C@@H]1[C@@H](C)[C@@]2(O)[C@H]([C@@H]3C(C)(C)[C@]13OC(=O)[C@@H](C)CC)[C@@H]1O[C@]1(CO)[C@@H](O)[C@]1(O)C(=O)C(C)=C[C@H]12- Mol. weight
- 562.66 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL3989916 ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05755113 | Phase 2 | Apr 13, 2023 | Memorial Sloan-Kettering Cancer Center, QBiotics Group Limited |
| NCT05608876 | Phase 2 | Nov 30, 2022 | QBiotics Group Limited |
| NCT05234437 | Phase 2 | Mar 9, 2022 | Cairns Hospital, Melanoma Institute Australia, Princess Alexandra Hospital, QBiotics Group Limited |
| NCT04834973 | Phase 1/Phase 2 (Phase 2) | May 7, 2021 | Melanoma Institute Australia, Merck, QBiotics Group Limited |
Showing 4 of 4 trials
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Organizations
Research & Development (6)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| QBiotics Group Limited | For profit | 4 | 4 | 1 | 2021 |
| Melanoma Institute Australia | Academic/Hospital | 2 | 0 | 1 | 2021 |
| Cairns Hospital | Academic/Hospital | 1 | 0 | 1 | 2022 |
| Memorial Sloan-Kettering Cancer Center | Academic/Hospital | 1 | 0 | 1 | 2023 |
| Merck | For profit | 1 | 0 | 1 | 2021 |
| Princess Alexandra Hospital | Academic/Hospital | 1 | 0 | 1 | 2022 |
6 organizations
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