Lufotrelvir
Small moleculeexperimentalCOVID-19
Clinical trial activity
4 trials · 11 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
1
Phase 3
1
Phase 4
0
Earliest trial started Sep 9, 2020 (NCT04535167)
Timeline
Indications
Mechanism of action
- Replicase polyprotein 1aINHIBITOR
Replicase polyprotein 1a inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
COc1cccc2[nH]c(C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]3CCNC3=O)C(=O)COP(=O)(O)O)cc12- Mol. weight
- 552.52 g/mol
- Lipinski Ro5
- 2 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Prodrug
Sources
- ChEMBLCHEMBL4802214 ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05050682 | Phase 1 | Oct 7, 2021 | Pfizer |
| NCT05780541 | Phase 3 | Sep 15, 2021 | AIDS Clinical Trials Group, Cardiothoracic Surgical Trials Network, Department of Veteran Affairs, International Network for Strategic Initiatives in Global HIV Trials (INSIGHT), Medical Research Council, National Heart, Lung, and Blood Institute (NHLBI), National Institute of Allergy and Infectious Diseases (NIAID), Pfizer, University of Copenhagen, University of Minnesota, University of New South Wales |
| NCT04627532 | Phase 1 | Oct 23, 2020 | Pfizer |
| NCT04535167 | Phase 1 | Sep 9, 2020 | Pfizer |
Showing 4 of 4 trials
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Organizations
Research & Development (11)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Pfizer | For profit | 4 | 3 | 2 | 2020 |
| AIDS Clinical Trials Group | Academic/Hospital | 1 | 0 | 1 | 2021 |
| Cardiothoracic Surgical Trials Network | Academic/Hospital | 1 | 0 | 1 | 2021 |
| Department of Veteran Affairs | Government | 1 | 0 | 1 | 2021 |
| International Network for Strategic Initiatives in Global HIV Trials (INSIGHT) | Academic/Hospital | 1 | 0 | 1 | 2021 |
| Medical Research Council | Government | 1 | 0 | 1 | 2021 |
| National Heart, Lung, and Blood Institute (NHLBI) | Government | 1 | 0 | 1 | 2021 |
| National Institute of Allergy and Infectious Diseases (NIAID) | Government | 1 | 1 | 1 | 2021 |
| University of Copenhagen | Academic/Hospital | 1 | 0 | 1 | 2021 |
| University of Minnesota | Academic/Hospital | 1 | 0 | 1 | 2021 |
| University of New South Wales | Academic/Hospital | 1 | 0 | 1 | 2021 |
11 organizations
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