cd19 car-nk cells
Cell therapyexperimental
Clinical trial activity
16 trials · 14 clinical orgs · 0 marketing orgs
Phase 1
16
Phase 2
0
Phase 3
0
Phase 4
0
Earliest trial started Dec 17, 2020 (NCT04639739)
Timeline
2020s
- Jan 1, 2020
Earliest Phase 1 Sponsor(trial)
Indications
Studied for
- Autoimmune Diseases · Phase 1
- Glomerulonephritis · Phase 1
- Hodgkin Disease · Phase 1
- Kidney Diseases · Phase 1
- Leukemia, B-Cell · Phase 1
- Leukemia, Lymphocytic, Chronic, B-Cell · Phase 1
- Lupus Erythematosus, Systemic · Phase 1
- Lupus Nephritis · Phase 1
- Lymphoma · Phase 1
- Lymphoma, B-Cell · Early Phase 1
- Lymphoma, Large-Cell, Immunoblastic · Phase 1
- Lymphoma, Mantle-Cell · Phase 1
- Lymphoma, Non-Hodgkin · Phase 1
- Myasthenia Gravis · Early Phase 1
- Myositis · Phase 1
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma · Phase 1
- Precursor Cell Lymphoblastic Leukemia-Lymphoma · Phase 1
- Scleroderma, Systemic · Phase 1
- Thrombocytopenia · Early Phase 1
- Vasculitis · Phase 1
- Waldenstrom Macroglobulinemia · Phase 1
Mechanism of action
- B-lymphocyte antigen CD19Immunity, passive
CD19 immunity, passive
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07243366 | Early Phase 1 (Phase 1) | Nov 25, 2025 | Guangdong ProCapZoom Biosciences Co., Ltd. |
| NCT06733935 | Phase 1 | Nov 4, 2024 | Nkarta Inc. |
| NCT06337474 | Early Phase 1 (Phase 1) | Aug 30, 2024 | Changzhou No.2 People's Hospital, Rui Therapeutics Co., Ltd |
| NCT06518668 | Phase 1 | Jul 1, 2024 | Columbia University |
| NCT06464679 | Phase 1 | Jun 27, 2024 | Changhai Hospital, Rui Therapeutics Co., Ltd |
| NCT06469190 | Early Phase 1 (Phase 1) | Jun 21, 2024 | Changhai Hospital, Rui Therapeutics Co., Ltd |
| NCT06557265 | Phase 1 | Jun 13, 2024 | Nkarta Inc. |
| NCT06010472 | Early Phase 1 (Phase 1) | Aug 24, 2023 | Changhai Hospital, Nanjing Enricnk Biotech Co., Ltd, Rui Therapeutics Co., Ltd |
| NCT05739227 | Early Phase 1 (Phase 1) | Mar 1, 2023 | Xuzhou Medical University |
| NCT05645601 | Phase 1 | Dec 1, 2022 | Government of China, People's Liberation Army of China |
| NCT05472558 | Phase 1 | Sep 10, 2022 | Zhejiang University |
| NCT05563545 | Phase 1 | Jul 21, 2022 | SIMR |
| NCT05410041 | Phase 1 | May 25, 2022 | Beijing Boren Hospital |
| NCT05020678 | Phase 1 | Aug 20, 2021 | Nkarta Inc. |
| NCT04887012 | Phase 1 | May 1, 2021 | Zhejiang University |
| NCT04639739 | Early Phase 1 (Phase 1) | Dec 17, 2020 | Chongqing Precision Biotech Co., Ltd, People's Liberation Army of China |
Showing 16 of 16 trials
Page 1 / 1
Organizations
Research & Development (14)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Rui Therapeutics Co., Ltd | For profit | 4 | 0 | 1 | 2023 |
| Changhai Hospital | Academic/Hospital | 3 | 3 | 1 | 2023 |
| Nkarta Inc. | For profit | 3 | 3 | 1 | 2021 |
| People's Liberation Army of China | Government | 2 | 2 | 1 | 2020 |
| Zhejiang University | Academic/Hospital | 2 | 2 | 1 | 2021 |
| Beijing Boren Hospital | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Changzhou No.2 People's Hospital | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Chongqing Precision Biotech Co., Ltd | For profit | 1 | 0 | 1 | 2020 |
| Columbia University | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Government of China | Government | 1 | 0 | 1 | 2022 |
| Guangdong ProCapZoom Biosciences Co., Ltd. | For profit | 1 | 1 | 1 | 2025 |
| Nanjing Enricnk Biotech Co., Ltd | For profit | 1 | 0 | 1 | 2023 |
| SIMR | For profit | 1 | 1 | 1 | 2022 |
| Xuzhou Medical University | Academic/Hospital | 1 | 1 | 1 | 2023 |
14 organizations
Page 1 / 1