um-171
Small moleculeexperimental
UM171 is a potent agonist of human hematopoietic stem cell renewal, independently of AhR suppression. UM171 act differently than other small molecule stimulators of hematopoiesis, such as the aryl hydrocarbon receptor (AhR) antagonist StemRegenin 1 (SR1). Addition of UM171 to cultures containing SR1 and cytokines further enhances the ex vivo expansion of normal HSCs, including CD34+ cells. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Chemistry & pharmacology
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SMILES
CN1N=NC(=N1)C2=CC3=C(C=C2)C4=C(N3)N=C(CC5=CC=CC=C5)N=C4N[C@H]6CC[C@H](N)CC6- Mol. weight
- 453.5422 g/mol
Oral
No
Parenteral
No
Topical
No
Sources
- NCATS8XZ4J0KS9C ↗