jnj-28312141
Small moleculeexperimental
JNJ-28312141 is an orally active colony-stimulating factor-1 receptor and FMS-related receptor tyrosine kinase-3 inhibitor. In preclinical models, JNJ-28312141 caused regression of ITD-FLT3–dependent MV-4-11 AML xenografts. The drug also suppressed the growth of H460 non-small cell lung adenocarcinoma xenografts and inhibited osteoclastogenesis and osteolysis in a rat model of metastatic bone disease. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Chemistry & pharmacology
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SMILES
CN(C)CC(=O)N1CCC(CC1)C2=CC(C3=CCCCC3)=C(NC(=O)C4=NC(=CN4)C#N)C=C2- Mol. weight
- 460.5713 g/mol
Oral
No
Parenteral
No
Topical
No
Sources
- NCATSYKQ241VJ92 ↗