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plitidepsin

Small moleculeexperimental

Clinical trial activity

16 trials · 19 clinical orgs · 0 marketing orgs

Phase 1
5
Phase 2
13
Phase 3
2
Phase 4
0

Earliest trial started Dec 1, 2004 (NCT00884286)

Timeline

2000s

  1. Jan 1, 2004

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2007

    Earliest Phase 1 Sponsor(trial)

2010s

  1. Jan 1, 2010

    Earliest Phase 3 Sponsor(trial)

Indications

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

CC[C@H](C)[C@H]1NC(=O)[C@@H](NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H]2CCCN2C(=O)C(C)=O)[C@@H](C)OC(=O)[C@H](Cc2ccc(OC)cc2)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)C(=O)[C@H](C(C)C)OC(=O)C[C@@H]1O
Mol. weight
1110.36 g/mol
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • aplidin
  • aplidine
  • aplidine
  • aplidine
  • dehydrodidemnin b
  • dehydrodidemnin b
  • dehydrodidemnin b
  • dehydrodidemnin b
  • plitidepsin
  • plitidepsin
  • plitidepsin
  • plitidepsin
  • plitidepsin
  • plitidepsina
  • plitidepsina
  • plitidepsine
  • plitidepsine
  • plitidepsium
  • plitidepsium

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06766825Phase 2Feb 7, 2025FUNDACIÓN FLS DE LUCHA CONTRA EL SIDA, LAS ENFERMEDADES INFECCIOSAS Y LA PROMOCIÓN DE LA SALUD Y LA CIENCIA, IrsiCaixa, PharmaMar
NCT05705167Phase 2Apr 19, 2023PharmaMar
NCT05121740Phase 1/Phase 2 (Phase 2)Dec 13, 2021Apices Soluciones S.L., Badalona Hospital Germans Trias i Pujol, Clinica Quirón Salud, Córdoba, Hospital Universitario HM Montepríncipe, PharmaMar, Universidad Autonoma de Madrid
NCT04784559Phase 3Jun 4, 2021PharmaMar
NCT04382066Phase 1May 12, 2020Apices Soluciones S.L., Hospital Universitario Ramon y Cajal, PharmaMar, Universidad Complutense de Madrid
NCT03117361Phase 2Nov 15, 2016PharmaMar
NCT03070964Phase 2Nov 1, 2016PharmaMar
NCT02100657Phase 1Jun 1, 2014PharmaMar
NCT01876043Phase 2Feb 1, 2012Government of France, Institut Bergonié, PharmaMar
NCT01149681Phase 2Jul 1, 2010PharmaMar
NCT01102426Phase 3Jun 1, 2010Cornell University, Marshall University, PharmaMar
NCT00788099Phase 1Dec 1, 2008Institut Gustave Roussy, PharmaMar, Rutgers University
NCT00780143Phase 1/Phase 2 (Phase 2)Nov 1, 2007PharmaMar, Rutgers University
NCT00229203Phase 2Feb 1, 2005Harvard University, PharmaMar
NCT00780975Phase 2Feb 1, 2005PharmaMar, University of Michigan, University of Washington
NCT00884286Phase 2Dec 1, 2004Institut Gustave Roussy, PharmaMar
Showing 16 of 16 trials
Page 1 / 1

Organizations

Research & Development (19)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
PharmaMarFor profit161432004
Apices Soluciones S.L.For profit2022020
Institut Gustave RoussyAcademic/Hospital2022004
Rutgers UniversityAcademic/Hospital2022007
Badalona Hospital Germans Trias i PujolAcademic/Hospital1012021
Clinica Quirón Salud, CórdobaAcademic/Hospital1012021
Cornell UniversityAcademic/Hospital1012010
FUNDACIÓN FLS DE LUCHA CONTRA EL SIDA, LAS ENFERMEDADES INFECCIOSAS Y LA PROMOCIÓN DE LA SALUD Y LA CIENCIAAcademic/Hospital1112025
Government of FranceGovernment1012012
Harvard UniversityAcademic/Hospital1012005
Hospital Universitario HM MontepríncipeAcademic/Hospital1012021
Hospital Universitario Ramon y CajalAcademic/Hospital1012020
Institut BergoniéAcademic/Hospital1112012
IrsiCaixaAcademic/Hospital1012025
Marshall UniversityAcademic/Hospital1012010
Universidad Autonoma de MadridAcademic/Hospital1012021
Universidad Complutense de MadridAcademic/Hospital1012020
University of MichiganAcademic/Hospital1012005
University of WashingtonAcademic/Hospital1012005
19 organizations
Page 1 / 1