bromazepam
Small moleculeexperimental
Bromazepam, sold under many brand names, is a benzodiazepine. It is mainly an anti-anxiety agent with similar side effects to diazepam. In addition to being used to treat anxiety or panic states, bromazepam may be used as a premedicant prior to minor surgery. Bromazepam typically comes in doses of 1.5 mg, 3 mg and 6 mg tablets. — Wikipedia
Clinical trial activity
2 trials · 2 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
1
Phase 3
1
Phase 4
0
Earliest trial started Jan 1, 2015 (NCT02374567)
Timeline
2010s
- Jan 1, 2015
Earliest Phase 3 Sponsor(trial)
Indications
Mechanism of action
- GABA receptor alpha-2 subunitPOSITIVE ALLOSTERIC MODULATOR
GABRA2 positive allosteric modulator
Bromozepan acts in one of the allosteric sites of the GABA-A receptors by increasing the opening frequency of gamma-aminobutyric acid activated cloride channels.
Chemistry & pharmacology
Loading structure…
SMILES
O=C1CN=C(c2ccccn2)c2cc(Br)ccc2N1- Mol. weight
- 316.16 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaBromazepam ↗
- ChEMBLCHEMBL277062 ↗
Also known as
- bromazepam
- bromazepam
- bromazepam
- bromazepam
- bromazepam
- bromazepam
- bromazepam
- bromazepam
- bromazepamum
- bromazepamum
- bromezapam
- durazanil
- lectopam
- lectopam
- lectopam
- lexotan
- lexotan
- ro-53350
- ro-53350
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04410536 | N/A | Jun 30, 2020 | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta |
| NCT02374567 | Phase 3 | Jan 1, 2015 | Gottfried Wilhelm Leibniz Universität Hannover |
Showing 2 of 2 trials
Page 1 / 1
Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | Academic/Hospital | 1 | 1 | 1 | 2020 |
| Gottfried Wilhelm Leibniz Universität Hannover | Academic/Hospital | 1 | 1 | 1 | 2015 |
2 organizations
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