sodium copper chlorophyllin
Chlorophyllin is a water soluble derivative of chlorophyll. It has chemopreventive properties and forms a non-covalent complex with many mutagenic/carcinogenic molecules. Chlorophyllin inhibits cancer initiation and progression by targeting multiple molecules and pathways involved in the metabolism of carcinogens, cell cycle progression, apoptosis evasion, invasion, and angiogenesis. The modulatory effects of Chlorophyllin to be mediated via abrogation of key oncogenic signal transduction pathways such as nuclear factor kappa B, Wnt/β-catenin, and phosphatidylinositol-3-kinase/Akt signaling. Chlorophyllin sodium copper salt mitigates radiation-induced hematopoietic syndrome by increasing the abundance of hematopoietic stem cells, enhancing granulopoiesis, and stimulating prosurvival pathways in bone marrow cells and lymphocytes. In addition, chlorophyllin exhibits antioxidant, antiapoptotic and immunostimulatory effects. Chlorophyllin is intended to improve the quality of life in people who have fecal incontinence due to spinal cord injury, bowel cancer, psychotic disorder, terminal illness, or other disorders. Chlorophyllin is also used by people who have had a colostomy or ileostomy — NCATS
Clinical trial activity
4 trials · 2 clinical orgs · 0 marketing orgs
Earliest trial started Mar 26, 2022 (NCT05348239)
Timeline
Indications
Approved for
Mechanism of action
- Unspecified targetAntioxidant
Antioxidant
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- NCATS1D276TYV9O ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07164534 | Phase 3 | Sep 30, 2025 | Tata Memorial Hospital |
| NCT06016452 | Phase 2 | Nov 13, 2023 | Tata Memorial Hospital |
| NCT05856305 | Phase 2 | Jul 5, 2023 | Tata Memorial Hospital |
| NCT05348239 | Phase 2 | Mar 26, 2022 | Government of India, Tata Memorial Hospital |
Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Tata Memorial Hospital | Academic/Hospital | 4 | 4 | 2 | 2022 |
| Government of India | Government | 1 | 0 | 1 | 2022 |