sodium copper chlorophyllin

Small moleculeexperimental

Chlorophyllin is a water soluble derivative of chlorophyll. It has chemopreventive properties and forms a non-covalent complex with many mutagenic/carcinogenic molecules. Chlorophyllin inhibits cancer initiation and progression by targeting multiple molecules and pathways involved in the metabolism of carcinogens, cell cycle progression, apoptosis evasion, invasion, and angiogenesis. The modulatory effects of Chlorophyllin to be mediated via abrogation of key oncogenic signal transduction pathways such as nuclear factor kappa B, Wnt/β-catenin, and phosphatidylinositol-3-kinase/Akt signaling. Chlorophyllin sodium copper salt mitigates radiation-induced hematopoietic syndrome by increasing the abundance of hematopoietic stem cells, enhancing granulopoiesis, and stimulating prosurvival pathways in bone marrow cells and lymphocytes. In addition, chlorophyllin exhibits antioxidant, antiapoptotic and immunostimulatory effects. Chlorophyllin is intended to improve the quality of life in people who have fecal incontinence due to spinal cord injury, bowel cancer, psychotic disorder, terminal illness, or other disorders. Chlorophyllin is also used by people who have had a colostomy or ileostomy — NCATS

Clinical trial activity

4 trials · 2 clinical orgs · 0 marketing orgs

Phase 1
0
Phase 2
4
Phase 3
1
Phase 4
0

Earliest trial started Mar 26, 2022 (NCT05348239)

Timeline

2020s

  1. Jan 1, 2022

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2025

    Earliest Phase 3 Sponsor(trial)

Indications

Approved for

Mechanism of action

  • Unspecified targetAntioxidant

    Antioxidant

Chemistry & pharmacology

Oral

No

Parenteral

No

Topical

No

Sources

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07164534Phase 3Sep 30, 2025Tata Memorial Hospital
NCT06016452Phase 2Nov 13, 2023Tata Memorial Hospital
NCT05856305Phase 2Jul 5, 2023Tata Memorial Hospital
NCT05348239Phase 2Mar 26, 2022Government of India, Tata Memorial Hospital
Showing 4 of 4 trials
Page 1 / 1

Organizations

Research & Development (2)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Tata Memorial HospitalAcademic/Hospital4422022
Government of IndiaGovernment1012022
2 organizations
Page 1 / 1