bcma/cd19 dual-target car-t
Cell therapyexperimental
Clinical trial activity
40 trials · 24 clinical orgs · 0 marketing orgs
Phase 1
33
Phase 2
6
Phase 3
0
Phase 4
0
Earliest trial started Oct 15, 2019 (NCT04182581)
Timeline
Indications
Studied for
- Adoptive Transfer · Phase 1
- Amyloidosis · Early Phase 1
- Anemia, Hemolytic, Autoimmune · Phase 1
- Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis · Phase 2
- Antiphospholipid Syndrome · Phase 2
- Arthritis, Rheumatoid · Early Phase 1
- Autoimmune Diseases · Phase 2
- Behcet Syndrome · Phase 2
- Immune System Diseases · Phase 1
- Immunoglobulin G4-Related Disease · Phase 2
- Immunotherapy, Adoptive · Phase 1
- Leukemia, Lymphocytic, Chronic, B-Cell · Early Phase 1
- Lupus Erythematosus, Cutaneous · Phase 1
- Lupus Erythematosus, Systemic · Phase 2
- Lupus Nephritis · Phase 1/Phase 2
- Lymphoma · Phase 1
- Lymphoma, Non-Hodgkin · Early Phase 1
- Microscopic Polyangiitis · Phase 1/Phase 2
- Multiple Myeloma · Phase 1
- Myasthenia Gravis · Phase 1
- Myositis · Phase 2
- POEMS Syndrome · Early Phase 1
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma · Early Phase 1
- Purpura · Phase 2
- Scleroderma, Systemic · Phase 1/Phase 2
- Sclerosis · Phase 2
- Sjogren's Syndrome · Phase 2
- Vasculitis · Early Phase 1
- Vasculitis, Central Nervous System · Phase 1/Phase 2
Mechanism of action
- B-lymphocyte antigen CD19Immunity, passive
CD19 immunity, passive
- BCMAImmunity, passive
BCMA immunity, passive
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07261345 | Early Phase 1 (Phase 1) | Dec 31, 2026 | Fudan University |
| NCT07298590 | Early Phase 1 (Phase 1) | Dec 30, 2025 | Changhai Hospital |
| NCT07266337 | Early Phase 1 (Phase 1) | Dec 10, 2025 | Government of China, People's Liberation Army of China |
| NCT07283315 | Early Phase 1 (Phase 1) | Dec 3, 2025 | Rui Therapeutics Co., Ltd, Zhejiang University |
| NCT07241468 | Early Phase 1 (Phase 1) | Nov 30, 2025 | Changhai Hospital, Rui Therapeutics Co., Ltd |
| NCT07246096 | Early Phase 1 (Phase 1) | Nov 20, 2025 | Changhai Hospital, Rui Therapeutics Co., Ltd |
| NCT06947473 | Phase 1/Phase 2 (Phase 2) | Sep 18, 2025 | Government of China |
| NCT07148791 | Phase 2 | Sep 5, 2025 | People's Liberation Army of China, Xuzhou Medical University |
| NCT06986434 | Early Phase 1 (Phase 1) | Aug 26, 2025 | People's Liberation Army of China |
| NCT07121777 | N/A | Aug 25, 2025 | Anhui Medical University |
| NCT06973356 | N/A | Aug 16, 2025 | Anhui Medical University, University of Science and Technology of China |
| NCT07077330 | Early Phase 1 (Phase 1) | Aug 1, 2025 | People's Liberation Army of China |
| NCT07052565 | N/A | Jul 20, 2025 | Anhui Medical University |
| NCT07072247 | Phase 1 | Jul 10, 2025 | Allorunning Therapeutics, Soochow University |
| NCT06978738 | Phase 1 | May 31, 2025 | Changzhou No.2 People's Hospital |
| NCT07003555 | Phase 1 | May 25, 2025 | Government of China, Jiao Tong University, Shanghai Liquan Hospital |
| NCT06947460 | Phase 1/Phase 2 (Phase 2) | Apr 18, 2025 | Government of China |
| NCT06961669 | N/A | Apr 16, 2025 | Anhui Medical University, University of Science and Technology of China |
| NCT07249073 | Early Phase 1 (Phase 1) | Mar 28, 2025 | China Academy of Chinese Medical Sciences, Government of China |
| NCT07274059 | Early Phase 1 (Phase 1) | Mar 26, 2025 | Government of China, People's Liberation Army of China, Yancheng Third People's Hospital |
Showing 20 of 40 trials
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Organizations
Research & Development (24)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Zhejiang University | Academic/Hospital | 8 | 8 | 1 | 2020 |
| People's Liberation Army of China | Government | 7 | 4 | 2 | 2019 |
| Yake Biotechnology Ltd. | Government | 7 | 0 | 1 | 2020 |
| Government of China | Government | 6 | 5 | 2 | 2025 |
| Anhui Medical University | Academic/Hospital | 4 | 4 | 1 | 2025 |
| Changhai Hospital | Academic/Hospital | 3 | 3 | 1 | 2025 |
| iCell Gene Therapeutics | For profit | 3 | 3 | 1 | 2019 |
| Rui Therapeutics Co., Ltd | For profit | 3 | 0 | 1 | 2025 |
| University of Science and Technology of China | Academic/Hospital | 3 | 1 | 1 | 2024 |
| China Academy of Chinese Medical Sciences | Academic/Hospital | 2 | 2 | 1 | 2024 |
| Essen Biotech | For profit | 2 | 2 | 1 | 2024 |
| Gracell Biotechnology Ltd. | For profit | 2 | 0 | 1 | 2019 |
| Jiao Tong University | Academic/Hospital | 2 | 1 | 1 | 2024 |
| Peking University | Academic/Hospital | 2 | 1 | 2 | 2019 |
| Allorunning Therapeutics | For profit | 1 | 0 | 1 | 2025 |
| Changzhou No.2 People's Hospital | Academic/Hospital | 1 | 1 | 1 | 2025 |
| Fudan University | Academic/Hospital | 1 | 1 | 1 | 2026 |
| Ludaopei Hospital | Academic/Hospital | 1 | 1 | 1 | 2020 |
| Shanghai Liquan Hospital | Academic/Hospital | 1 | 0 | 1 | 2025 |
| Soochow University | Academic/Hospital | 1 | 1 | 1 | 2025 |
24 organizations
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