cocarboxylase
Small moleculeexperimental
Cocarboxylase is the coenzyme form of Vitamin B1 present in many animal tissues. Thiamine pyrophosphate (cocarboxylase) is the active form of thiamine, and it serves as a cofactor for several enzymes involved primarily in carbohydrate catabolism. Pancreatic cells obtain thiamin from their surroundings and enzymatically convert it into thiamin pyrophosphate (TPP) in the cytoplasm; TPP is then taken up by mitochondria via a specific carrier the mitochondrial TPP transporter (MTPPT; product of the SLC25A19 gene). — NCATS
Clinical trial activity
1 trials · 1 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Earliest trial started Oct 3, 2018 (NCT03877523)
Timeline
No events for the selected filters.
Indications
Approved for
Studied for
Chemistry & pharmacology
Loading structure…
SMILES
[H+].CC1=C(CCOP([O-])(=O)OP(O)([O-])=O)SC=[N+]1CC2=CN=C(C)N=C2N- Mol. weight
- 424.306 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaThiamine pyrophosphate ↗
- NCATSQ57971654Y ↗
- ChEMBLCHEMBL2104121 ↗
- ChEMBLCHEMBL1236376 ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03877523 | N/A | Oct 3, 2018 | Institute for Atherosclerosis Research, Russia |
Showing 1 of 1 trials
Page 1 / 1
Organizations
Research & Development (1)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Institute for Atherosclerosis Research, Russia | Academic/Hospital | 1 | 1 | 1 | 2018 |
1 organizations
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