brain natriuretic peptide
Brain natriuretic peptide (BNP), also known as B-type natriuretic peptide, is a peptide hormone secreted by cardiomyocytes in the heart ventricles in response to stretching caused by increased ventricular blood volume. BNP is one of the three natriuretic peptides, in addition to atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). BNP was first discovered in porcine brain tissue in 1988, which led to its initial naming as "brain natriuretic peptide", although subsequent research revealed that BNP is primarily produced and secreted by the ventricular myocardium in response to increased ventricular blood volume and stretching. To reflect its true source, BNP is now often referred to as "B-type natriuretic peptide" while retaining the same acronym. — Wikipedia
Clinical trial activity
10 trials · 10 clinical orgs · 0 marketing orgs
Earliest trial started Aug 1, 2002 (NCT00252213)
Timeline
Indications
Approved for
Mechanism of action
- Unspecified targetAGONIST
Agonist
Chemistry & pharmacology
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaBrain natriuretic peptide 32 ↗
- WikipediaVentricular natriuretic peptide ↗
Also known as
- human bnp
- human bnp-32
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07086287 | N/A | Aug 1, 2025 | Anhui Medical University |
| NCT06745206 | Phase 1/Phase 2 (Phase 2) | Dec 31, 2024 | Sichuan University |
| NCT05716984 | Phase 4 | Apr 15, 2023 | Shengjing Hospital |
| NCT05723315 | N/A | Feb 20, 2023 | Chinese Academy of Medical Sciences, Henan Institute of Cardiovascular Epidemiology |
| NCT05111769 | N/A | Dec 1, 2021 | Fudan University |
| NCT04157868 | Phase 4 | Nov 30, 2019 | Jiao Tong University |
| NCT04033861 | Phase 3 | Aug 1, 2019 | Jiao Tong University |
| NCT03397966 | Phase 4 | Jul 1, 2018 | Department of Veteran Affairs |
| NCT01324739 | N/A | May 1, 2010 | University of Vienna |
| NCT00252213 | Phase 1 | Aug 1, 2002 | Mayo Clinic |
Organizations
Research & Development (10)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Jiao Tong University | Academic/Hospital | 2 | 2 | 2 | 2019 |
| Anhui Medical University | Academic/Hospital | 1 | 1 | 1 | 2025 |
| Chinese Academy of Medical Sciences | Academic/Hospital | 1 | 0 | 1 | 2023 |
| Department of Veteran Affairs | Government | 1 | 1 | 1 | 2018 |
| Fudan University | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Henan Institute of Cardiovascular Epidemiology | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Mayo Clinic | Academic/Hospital | 1 | 1 | 1 | 2002 |
| Shengjing Hospital | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Sichuan University | Academic/Hospital | 1 | 1 | 1 | 2024 |
| University of Vienna | Academic/Hospital | 1 | 1 | 1 | 2010 |