beta-hydroxybutyrate
Small moleculeexperimental
β-Hydroxybutyric acid, also known as 3-hydroxybutyric acid or BHB, is an organic compound and a beta hydroxy acid with the chemical formula CH3CH(OH)CH2CO2H; its conjugate base is β-hydroxybutyrate, also known as 3-hydroxybutyrate. β-Hydroxybutyric acid is a chiral compound with two enantiomers: D-β-hydroxybutyric acid and L-β-hydroxybutyric acid. Its oxidized and polymeric derivatives occur widely in nature. In humans, D-β-hydroxybutyric acid is one of two primary endogenous agonists of hydroxycarboxylic acid receptor 2 (HCA2), a Gi/o-coupled G protein-coupled receptor (GPCR). — Wikipedia
Clinical trial activity
21 trials · 20 clinical orgs · 0 marketing orgs
Phase 1
5
Phase 2
3
Phase 3
0
Phase 4
0
Earliest trial started Nov 1, 2014 (NCT02471040)
Timeline
Indications
Mechanism of action
- Unspecified targetSupplementation
supplementation
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaΒ-Hydroxybutyric acid ↗
- WikipediaBeta-Hydroxybutyric acid ↗
Also known as
- beta-hydroxybutyrate
- beta-hydroxybutyrate
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07218497 | Phase 1 | Nov 1, 2025 | University of Southern California |
| NCT07010666 | N/A | Jan 29, 2025 | University of South Carolina |
| NCT06351124 | Phase 1/Phase 2 (Phase 2) | Aug 28, 2024 | University of Texas, Austin |
| NCT06104670 | N/A | Nov 2, 2023 | Mayo Clinic, Sanford Health |
| NCT05980858 | N/A | Aug 31, 2023 | Gødstrup Hospital |
| NCT05477368 | N/A | Sep 28, 2022 | University of British Columbia |
| NCT05119010 | N/A | Nov 8, 2021 | Institut Gustave Roussy |
| NCT04820478 | Phase 2 | Nov 1, 2021 | University of Ulm |
| NCT04881526 | N/A | Jun 1, 2021 | University of Guelph |
| NCT04573764 | N/A | Feb 1, 2021 | Steno Diabetes Center Copenhagen, University of Copenhagen |
| NCT04791787 | N/A | Nov 25, 2020 | University of Texas, San Antonio |
| NCT04490226 | N/A | Aug 21, 2020 | University of Kiel |
| NCT04370600 | Phase 1 | Jun 30, 2020 | Thomas Jefferson University |
| NCT04379934 | N/A | Jun 1, 2020 | Aarhus University |
| NCT04056286 | N/A | Jun 17, 2019 | Aarhus University, Arla Foods |
| NCT03935841 | N/A | Jun 1, 2019 | Aarhus University |
| NCT03560323 | Phase 1 | Dec 1, 2018 | University of Texas, San Antonio |
| NCT03132233 | N/A | May 8, 2017 | University of Bern |
| NCT02917252 | N/A | Feb 1, 2017 | Aarhus University |
| NCT02776488 | Phase 1/Phase 2 (Phase 2) | Jul 1, 2016 | University of California, Los Angeles |
Showing 20 of 21 trials
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Organizations
Research & Development (20)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Aarhus University | Academic/Hospital | 4 | 4 | 1 | 2017 |
| University of Texas, San Antonio | Academic/Hospital | 2 | 2 | 2 | 2018 |
| Arla Foods | For profit | 1 | 0 | 1 | 2019 |
| Gødstrup Hospital | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Institut Gustave Roussy | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Mayo Clinic | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Sanford Health | Academic/Hospital | 1 | 0 | 1 | 2023 |
| Steno Diabetes Center Copenhagen | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Thomas Jefferson University | Academic/Hospital | 1 | 1 | 1 | 2020 |
| University of Bern | Academic/Hospital | 1 | 1 | 1 | 2017 |
| University of British Columbia | Academic/Hospital | 1 | 1 | 1 | 2022 |
| University of California, Los Angeles | Academic/Hospital | 1 | 1 | 1 | 2016 |
| University of Copenhagen | Academic/Hospital | 1 | 0 | 1 | 2021 |
| University of Guelph | Academic/Hospital | 1 | 1 | 1 | 2021 |
| University of Kiel | Academic/Hospital | 1 | 1 | 1 | 2020 |
| University of South Carolina | Academic/Hospital | 1 | 1 | 1 | 2025 |
| University of Southern California | Academic/Hospital | 1 | 1 | 1 | 2025 |
| University of Texas, Austin | Academic/Hospital | 1 | 1 | 1 | 2024 |
| University of Ulm | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Yale University | Academic/Hospital | 1 | 1 | 1 | 2014 |
20 organizations
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