Doxofylline
Small moleculeexperimental
Doxofylline is a phosphodiesterase inhibiting bronchodilator used in the treatment of chronic respiratory diseases such as asthma and COPD. Like theophylline, it is a xanthine derivative. — Wikipedia
Clinical trial activity
4 trials · 5 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
1
Phase 3
1
Phase 4
2
Earliest trial started Dec 1, 2008 (NCT01055041)
Timeline
2010s
- Jan 1, 2019
Earliest Phase 3 Sponsor(trial)
Indications
Approved for
Mechanism of action
- Unspecified targetUnclear
Unclear
Chemistry & pharmacology
Loading structure…
SMILES
Cn1c(=O)c2c(ncn2CC2OCCO2)n(C)c1=O- Mol. weight
- 266.26 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaDoxofylline ↗
- ChEMBLCHEMBL1527608 ↗
Also known as
- 1h-purine-2,6-dione, 7-(1,3-dioxolan-2-ylmethyl)-3,7-dihydro-1,3-dimethyl-
- 2-(7'-theophyllinemethyl)1,3-dioxolane
- ansimar
- dioxyfilline
- doxofylline
- doxofylline
- doxofylline
- doxofylline
- doxofylline
- doxofylline
- doxofylline
- doxophylline
- doxophylline
- doxophylline
- doxophylline
- doxophylline
- tmdo
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04238221 | Phase 4 | Mar 1, 2020 | University of Milan |
| NCT03879590 | Phase 3 | May 31, 2019 | Universidad Autonoma de Nuevo Leon |
| NCT03388853 | Phase 4 | Jan 31, 2018 | NeuTec Pharma |
| NCT01055041 | N/A | Dec 1, 2008 | Government Medical College, Bhavnagar, Sir T. General Hospital and Government Medical College |
Showing 4 of 4 trials
Page 1 / 1
Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Government Medical College, Bhavnagar | Academic/Hospital | 1 | 1 | 1 | 2008 |
| NeuTec Pharma | For profit | 1 | 1 | 1 | 2018 |
| Sir T. General Hospital and Government Medical College | Academic/Hospital | 1 | 0 | 1 | 2008 |
| Universidad Autonoma de Nuevo Leon | Academic/Hospital | 1 | 1 | 1 | 2019 |
| University of Milan | Academic/Hospital | 1 | 1 | 1 | 2020 |
5 organizations
Page 1 / 1