seclidemstat
Small moleculeexperimental
Clinical trial activity
5 trials · 5 clinical orgs · 0 marketing orgs
Phase 1
5
Phase 2
2
Phase 3
0
Phase 4
0
Earliest trial started Jun 4, 2018 (NCT03600649)
Timeline
2010s
- Jan 1, 2018
Earliest Phase 1 Sponsor(trial)
Indications
Studied for
- Chondrosarcoma · Phase 1/Phase 2
- Desmoplastic Small Round Cell Tumor · Phase 1/Phase 2
- Endometrial Neoplasms · Phase 1
- Fibrosarcoma · Phase 1/Phase 2
- Leukemia, Myelomonocytic, Chronic · Phase 1/Phase 2
- Liposarcoma, Myxoid · Phase 1/Phase 2
- Myelodysplastic Syndromes · Phase 1/Phase 2
- Myoepithelioma · Phase 1/Phase 2
- Neoplasms · Phase 1/Phase 2
- Ovarian Neoplasms · Phase 1
- Sarcoma · Phase 1/Phase 2
- Sarcoma, Clear Cell · Phase 1/Phase 2
- Sarcoma, Ewing · Phase 1/Phase 2
Mechanism of action
- LSD1/CoREST complexINHIBITOR
LSD1/CoREST complex inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
C/C(=N\NC(=O)c1cccc(S(=O)(=O)N2CCN(C)CC2)c1)c1cc(Cl)ccc1O- Mol. weight
- 450.95 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL4297641 ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05266196 | Phase 1/Phase 2 (Phase 2) | Jan 15, 2022 | Salarius Pharmaceuticals, LLC |
| NCT04734990 | Phase 1/Phase 2 (Phase 2) | Jul 7, 2021 | University of Texas at Houston |
| NCT04611139 | Phase 1 | Dec 31, 2020 | HonorHealth Research Institute, Merck, Salarius Pharmaceuticals, LLC |
| NCT03895684 | Phase 1 | Apr 30, 2019 | Salarius Pharmaceuticals, LLC |
| NCT03600649 | Phase 1 | Jun 4, 2018 | Salarius Pharmaceuticals, LLC, University of South Florida |
Showing 5 of 5 trials
Page 1 / 1
Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Salarius Pharmaceuticals, LLC | For profit | 4 | 3 | 2 | 2018 |
| HonorHealth Research Institute | Academic/Hospital | 1 | 1 | 1 | 2020 |
| Merck | For profit | 1 | 0 | 1 | 2020 |
| University of South Florida | Academic/Hospital | 1 | 0 | 1 | 2018 |
| University of Texas at Houston | Academic/Hospital | 1 | 1 | 1 | 2021 |
5 organizations
Page 1 / 1