aspartame
Small moleculeexperimental
Aspartame is an artificial non-saccharide sweetener commonly used as a sugar substitute in foods and beverages. 200 times sweeter than sucrose, it is a methyl ester of the aspartic acid/phenylalanine dipeptide with brand names NutraSweet, Equal, and Canderel. Discovered in 1965, aspartame was approved by the US Food and Drug Administration (FDA) in 1974 and re-approved in 1981 after its initial approval was briefly revoked. — Wikipedia
Clinical trial activity
14 trials · 19 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
1
Phase 3
1
Phase 4
1
Earliest trial started Jan 1, 2006 (NCT01115088)
Timeline
2010s
- Jan 1, 2019
Earliest Phase 3 Sponsor(trial)
Indications
Approved for
Mechanism of action
TAS1R2 agonist
TAS1R3 agonist
- Unspecified targetOTHER
Sweetener
Chemistry & pharmacology
Loading structure…
SMILES
COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O- Mol. weight
- 294.31 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaAspartame ↗
- ChEMBLCHEMBL171679 ↗
Also known as
- 1-methyl n-l-alpha-aspartyl-l-phenylalanate
- 1-methyl n-l-alpha-aspartyl-l-phenylalanate
- 1-methyl n-l-alpha-aspartyl-l-phenylalanine
- 1-methyl n-l-alpha-aspartyl-l-phenylalanine
- 1-methyl n-l-α-aspartyl-l-phenylalanate
- 1-methyl n-l-α-aspartyl-l-phenylalanate
- 3-amino-n-(alpha-carboxyphenethyl)succinamic acid n-methyl ester
- 3-amino-n-(alpha-carboxyphenethyl)succinamic acid n-methyl ester
- 3-amino-n-(alpha-methoxycarbonylphenethyl) succinamic acid
- 3-amino-n-(alpha-methoxycarbonylphenethyl) succinamic acid
- 3-amino-n-(α-carboxyphenethyl)succinamic acid n-methyl ester
- 3-amino-n-(α-carboxyphenethyl)succinamic acid n-methyl ester
- 3-amino-n-(α-methoxycarbonylphenethyl) succinamic acid
- 3-amino-n-(α-methoxycarbonylphenethyl) succinamic acid
- apm
- apm
- aspartam
- aspartam
- aspartame
- aspartame
- aspartame
- aspartame
- aspartamo
- aspartamo
- aspartamum
- aspartamum
- aspartylphenylalanine methyl ester
- aspartylphenylalanine methyl ester
- asp-phe-ome
- asp-phe-ome
- e951
- e951
- l-aspartyl-l-phenylalanine methyl ester
- l-aspartyl-l-phenylalanine methyl ester
- sc-18862
- sc-18862
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04584242 | Phase 4 | Sep 3, 2020 | Yonsei University |
| NCT03992365 | Phase 3 | Jun 10, 2019 | China Medical University, Universal Integrated Corp. |
| NCT03954418 | N/A | Jun 1, 2019 | Aarhus University |
| NCT03259685 | N/A | Oct 18, 2017 | Laval University |
| NCT02934321 | N/A | Jun 29, 2017 | University of Florida |
| NCT02569762 | N/A | Jul 1, 2016 | University of Manitoba |
| NCT03232008 | N/A | Sep 1, 2015 | University of London |
| NCT02459535 | N/A | Mar 31, 2015 | German Institute of Human Nutrition, Ludwig Maximilians University |
| NCT01103921 | N/A | Oct 31, 2008 | National Heart, Lung, and Blood Institute (NHLBI), University of California, Davis |
| NCT00731510 | N/A | Jun 1, 2008 | Bangor University, Medical Expeditions Ltd, Science in Sport, United States Army |
| NCT00777647 | N/A | May 31, 2008 | Aarhus University, LG |
| NCT00776971 | N/A | Nov 30, 2007 | Aarhus University, LG |
| NCT01799096 | N/A | Sep 1, 2006 | University of Hull |
| NCT01115088 | N/A | Jan 1, 2006 | University of Vermont |
Showing 14 of 14 trials
Page 1 / 1
Organizations
Research & Development (19)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Aarhus University | Academic/Hospital | 3 | 3 | 1 | 2007 |
| LG | For profit | 2 | 0 | 1 | 2007 |
| Bangor University | Academic/Hospital | 1 | 0 | 1 | 2008 |
| China Medical University | Academic/Hospital | 1 | 0 | 1 | 2019 |
| German Institute of Human Nutrition | Academic/Hospital | 1 | 1 | 1 | 2015 |
| Laval University | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Ludwig Maximilians University | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Medical Expeditions Ltd | Academic/Hospital | 1 | 1 | 1 | 2008 |
| National Heart, Lung, and Blood Institute (NHLBI) | Government | 1 | 0 | 1 | 2008 |
| Science in Sport | For profit | 1 | 0 | 1 | 2008 |
| United States Army | Government | 1 | 0 | 1 | 2008 |
| Universal Integrated Corp. | For profit | 1 | 1 | 1 | 2019 |
| University of California, Davis | Academic/Hospital | 1 | 1 | 1 | 2008 |
| University of Florida | Academic/Hospital | 1 | 1 | 1 | 2017 |
| University of Hull | Academic/Hospital | 1 | 1 | 1 | 2006 |
| University of London | Academic/Hospital | 1 | 1 | 1 | 2015 |
| University of Manitoba | Academic/Hospital | 1 | 1 | 1 | 2016 |
| University of Vermont | Academic/Hospital | 1 | 1 | 1 | 2006 |
| Yonsei University | Academic/Hospital | 1 | 1 | 1 | 2020 |
19 organizations
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