oxalate decarboxylase

Recombinant proteinexperimental

In enzymology, an oxalate decarboxylase (EC 4.1.1.2) is an oxalate degrading enzyme that catalyzes the chemical reactionoxalate + H+ formate + CO2 — Wikipedia

Clinical trial activity

2 trials · 3 clinical orgs · 0 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Earliest trial started May 1, 2010 (NCT01127087)

Timeline

2010s

Jan 1, 2010
Earliest Phase 1 Sponsor(trial)
Jan 1, 2019
Earliest Phase 3 Sponsor(trial)

Indications

Studied for

Hyperoxaluria · Phase 3

Mechanism of action

OxalateHYDROLYTIC ENZYME
Oxalate hydrolytic enzyme
OXDCSupplementation
OXDC supplementation

Chemistry & pharmacology

Inorganic: No
Polymer: No
Multi-specific: No

Oral

Parenteral

Topical

Sources

WikipediaOxalate decarboxylase ↗
ChEMBLCHEMBL4297818 ↗

Also known as

oxalate carboxy-lyase
oxalate decarboxylase
oxazyme
oxazyme
oxazyme

Clinical trials

NCT ID	Phase	Start date	Sponsor(s)
NCT03847090	Phase 3	Mar 28, 2019	Allena Pharmaceuticals
NCT01127087	Phase 1/Phase 2 (Phase 2)	May 1, 2010	Mayo Clinic, OxThera

Showing 2 of 2 trials

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Organizations

Research & Development (3)

Organization	Org type	Trials	As lead sponsor	Phases	Earliest year
Allena Pharmaceuticals	For profit	1	1	1	2019
Mayo Clinic	Academic/Hospital	1	1	1	2010
OxThera	For profit	1	0	1	2010

3 organizations

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