kynurenine
Small moleculeexperimental
l-Kynurenine is a metabolite of the amino acid l-tryptophan used in the production of niacin. — Wikipedia
Clinical trial activity
1 trials · 1 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
0
Phase 3
0
Phase 4
0
Earliest trial started Mar 1, 2017 (NCT03212430)
Timeline
2010s
- Jan 1, 2017
Earliest Phase 1 Sponsor(trial)
Indications
Studied for
Mechanism of action
- Indoleamine 2,3-dioxygenaseINHIBITOR
IDO1 inhibitor
- Tryptophan 2,3-dioxygenaseINHIBITOR
TDO2 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
Nc1ccccc1C(=O)C[C@H](N)C(=O)O- Mol. weight
- 208.22 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaKynurenine ↗
- ChEMBLCHEMBL498416 ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03212430 | Phase 1 | Mar 1, 2017 | University of Copenhagen |
Showing 1 of 1 trials
Page 1 / 1
Organizations
Research & Development (1)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Copenhagen | Academic/Hospital | 1 | 1 | 1 | 2017 |
1 organizations
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