autologous humanized anti-cd19 and anti-cd20 dual specific car-t cells
Cell therapyexperimental
Clinical trial activity
7 trials · 7 clinical orgs · 0 marketing orgs
Phase 1
6
Phase 2
1
Phase 3
0
Phase 4
0
Earliest trial started Oct 1, 2017 (NCT03271515)
Timeline
2010s
- Jan 1, 2017
Earliest Phase 1 Sponsor(trial)
Indications
Studied for
- Hodgkin Disease · Phase 1/Phase 2
- Leukemia · Phase 1
- Leukemia, Lymphocytic, Chronic, B-Cell · Phase 1/Phase 2
- Lymphoma · Phase 1/Phase 2
- Lymphoma, B-Cell, Marginal Zone · Phase 1/Phase 2
- Lymphoma, Follicular · Phase 1/Phase 2
- Lymphoma, Large B-Cell, Diffuse · Phase 1/Phase 2
- Lymphoma, Large-Cell, Immunoblastic · Phase 1/Phase 2
- Lymphoma, Mantle-Cell · Phase 1/Phase 2
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma · Phase 1
- Precursor Cell Lymphoblastic Leukemia-Lymphoma · Phase 1
Mechanism of action
- B-lymphocyte antigen CD20Immunity, passive
MS4A1 immunity, passive
- B-lymphocyte antigen CD19Immunity, passive
CD19 immunity, passive
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06879262 | Early Phase 1 (Phase 1) | Mar 15, 2025 | Huazhong University of Science and Technology |
| NCT06160362 | N/A | Oct 31, 2023 | Henan Medical University |
| NCT04486872 | Phase 1 | Jul 25, 2020 | Zhejiang University |
| NCT04186520 | Phase 1/Phase 2 (Phase 2) | Feb 1, 2020 | Medical College of Wisconsin |
| NCT04215016 | Phase 1 | Dec 31, 2019 | Fujian Medical University |
| NCT04049383 | Phase 1 | Oct 1, 2019 | Medical College of Wisconsin, University of Wisconsin |
| NCT03271515 | Phase 1 | Oct 1, 2017 | Beijing Doing Biomedical Co., Ltd. |
Showing 7 of 7 trials
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Organizations
Research & Development (7)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Medical College of Wisconsin | Academic/Hospital | 2 | 2 | 2 | 2019 |
| Beijing Doing Biomedical Co., Ltd. | For profit | 1 | 1 | 1 | 2017 |
| Fujian Medical University | Academic/Hospital | 1 | 1 | 1 | 2019 |
| Henan Medical University | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Huazhong University of Science and Technology | Academic/Hospital | 1 | 1 | 1 | 2025 |
| University of Wisconsin | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Zhejiang University | Academic/Hospital | 1 | 1 | 1 | 2020 |
7 organizations
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