tolerogenic dendritic cells
Cell therapyexperimental
Tolerogenic dendritic cells are heterogenous pool of dendritic cells with immuno-suppressive properties, priming immune system into tolerogenic state against various antigens. These tolerogenic effects are mostly mediated through regulation of T cells such as inducing T cell anergy, T cell apoptosis and induction of Tregs. Tol-DCs also affect local micro-environment toward tolerogenic state by producing anti-inflammatory cytokines. — Wikipedia
Clinical trial activity
7 trials · 7 clinical orgs · 0 marketing orgs
Phase 1
5
Phase 2
4
Phase 3
0
Phase 4
0
Earliest trial started Dec 31, 2016 (NCT03337165)
Timeline
Indications
Studied for
- Arthritis · Phase 1
- Arthritis, Rheumatoid · Phase 1
- Autoimmune Diseases · Phase 1
- Colorectal Neoplasms, Hereditary Nonpolyposis · Phase 1
- Connective Tissue Diseases · Phase 1
- Diabetes Mellitus · Phase 1/Phase 2
- Immune System Diseases · Phase 1
- Joint Diseases · Phase 1
- Kidney Transplantation · Phase 1
- Multiple Sclerosis · Phase 2
- Musculoskeletal Diseases · Phase 1
- Myocardial Infarction · Phase 1/Phase 2
- Rheumatic Diseases · Phase 1
Mechanism of action
- Unspecified targetImmunity, desensitized
immunity, desensitized
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaTolerogenic dendritic cell ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07020715 | Phase 2 | Dec 1, 2025 | Badalona Hospital Germans Trias i Pujol, University of Antwerp |
| NCT07163403 | Phase 1 | Sep 4, 2025 | University of Barcelona |
| NCT06852625 | Phase 1 | May 31, 2025 | University of Barcelona |
| NCT06715605 | Phase 2 | Apr 30, 2025 | University of Antwerp |
| NCT05207995 | Phase 1/Phase 2 (Phase 2) | Mar 1, 2022 | Belarusian State Medical University, National Academy of Sciences of Belarus |
| NCT05554484 | Phase 1/Phase 2 (Phase 2) | Jun 7, 2021 | Catholic University of Korea |
| NCT03337165 | Phase 1 | Dec 31, 2016 | Russian Academy of Medical Sciences |
Showing 7 of 7 trials
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Organizations
Research & Development (7)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Antwerp | Academic/Hospital | 2 | 2 | 1 | 2025 |
| University of Barcelona | Academic/Hospital | 2 | 2 | 1 | 2025 |
| Badalona Hospital Germans Trias i Pujol | Academic/Hospital | 1 | 0 | 1 | 2025 |
| Belarusian State Medical University | Academic/Hospital | 1 | 0 | 1 | 2022 |
| Catholic University of Korea | Academic/Hospital | 1 | 1 | 1 | 2021 |
| National Academy of Sciences of Belarus | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Russian Academy of Medical Sciences | Academic/Hospital | 1 | 1 | 1 | 2016 |
7 organizations
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