trichloroacetic acid
Trichloroacetic acid (TCA; TCAA) is a chemical used in skin peel formulations. It is more frequently used for lighter skin and is less used on darker skin because of the higher risks of scarring, as well as post-peel dyschromias. Low concentrations, 10-35% is preferred for skin peel formulations so that it only reaches the upper papillary dermis. Topical TCA is an efficacious treatment of internal anal high-grade squamous intraepithelial lesions (HSIL). Advantages of TCA for this recurrent disease process include low cost, no requirement for special equipment beyond that for high-resolution anoscopy, and painless application procedure. — NCATS
Clinical trial activity
12 trials · 11 clinical orgs · 0 marketing orgs
Earliest trial started Apr 30, 2018 (NCT03475524)
Timeline
2020s
- Jan 1, 2021
Earliest Phase 2 Sponsor(trial)
Indications
Approved for
Mechanism of action
- UnclearUnclear
Unclear unclear
Chemistry & pharmacology
SMILES
OC(=O)C(Cl)(Cl)Cl- Mol. weight
- 163.387 g/mol
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaTrichloroacetic acid ↗
- NCATS5V2JDO056X ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07060157 | N/A | Jul 22, 2025 | Assiut University |
| NCT06836791 | N/A | Mar 1, 2023 | Kafrelsheikh University |
| NCT05622916 | N/A | Nov 30, 2022 | University of Hasanuddin, University of Indonesia |
| NCT06008327 | N/A | Aug 1, 2022 | Jinnah Postgraduate Medical Centre, University of Karachi |
| NCT05712811 | N/A | Jun 1, 2022 | Government of Pakistan |
| NCT05712837 | N/A | Jun 1, 2022 | Government of Pakistan |
| NCT04889703 | N/A | Dec 31, 2021 | The University of Texas, Dallas |
| NCT04911075 | N/A | Apr 15, 2021 | University of Indonesia |
| NCT04797663 | Phase 4 | Mar 17, 2021 | Cairo University |
| NCT04429308 | Phase 2 | Jan 31, 2021 | Northwestern University |
| NCT05143398 | N/A | Sep 1, 2018 | Istituto Auxologico Italiano |
| NCT03475524 | Phase 4 | Apr 30, 2018 | Assiut University |
Organizations
Research & Development (11)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Assiut University | Academic/Hospital | 2 | 2 | 2 | 2018 |
| Government of Pakistan | Government | 2 | 2 | 1 | 2022 |
| University of Indonesia | Academic/Hospital | 2 | 1 | 1 | 2021 |
| Cairo University | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Istituto Auxologico Italiano | Academic/Hospital | 1 | 1 | 1 | 2018 |
| Jinnah Postgraduate Medical Centre | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Kafrelsheikh University | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Northwestern University | Academic/Hospital | 1 | 1 | 1 | 2021 |
| The University of Texas, Dallas | Academic/Hospital | 1 | 1 | 1 | 2021 |
| University of Hasanuddin | Academic/Hospital | 1 | 1 | 1 | 2022 |
| University of Karachi | Academic/Hospital | 1 | 0 | 1 | 2022 |