fenretinide
Peptideexperimental
Fenretinide (N-(4-hydroxyphenyl)retinamide; 4-HPR) (INN) is a synthetic retinoid derivative. Retinoids are substances related to vitamin A. It has been investigated for potential use in the treatment of cancer, as well as in the treatment of cystic fibrosis, rheumatoid arthritis, acne, psoriasis, and has been found to also slow the production and accumulation of a toxin that leads to vision loss in Stargardt's patients. — Wikipedia
Clinical trial activity
6 trials · 9 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
2
Phase 3
1
Phase 4
0
Earliest trial started Jun 30, 2018 (NCT03265288)
Timeline
Indications
Studied for
- COVID-19 · Phase 2/Phase 3
- Cystic Fibrosis · Phase 2
- Lymphoma, Follicular · Phase 1
- Lymphoma, T-Cell · Phase 1
- Lymphoma, T-Cell, Cutaneous · Phase 1
- Lymphoma, T-Cell, Peripheral · Phase 1
- Mycosis Fungoides · Phase 1
- Pharmacological and Toxicological Phenomena · Phase 1
- Sezary Syndrome · Phase 1
- Small Cell Lung Carcinoma · Phase 1
Mechanism of action
- UnclearUnclear
Unclear unclear
Chemistry & pharmacology
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaFenretinide ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06922539 | Phase 1 | Nov 28, 2025 | SciTech Development, LLC |
| NCT06181760 | Phase 1 | Nov 22, 2023 | Beyond Drug Development, Island Pharmaceuticals, Scientia Clinical Research Limited Sydney |
| NCT05999435 | Phase 2/Phase 3 (Phase 3) | Nov 20, 2023 | Laurent Pharmaceuticals Inc. |
| NCT04234048 | Phase 1 | Jul 31, 2020 | Rush University, SciTech Development, LLC |
| NCT04417257 | Phase 2 | Jun 8, 2020 | Laurent Pharmaceuticals Inc., McGill University |
| NCT03265288 | Phase 2 | Jun 30, 2018 | Case Western Reserve University, Cystic Fibrosis Foundation Therapeutics, Laurent Pharmaceuticals Inc., McGill University |
Showing 6 of 6 trials
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Organizations
Research & Development (9)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Laurent Pharmaceuticals Inc. | For profit | 3 | 3 | 2 | 2018 |
| McGill University | Academic/Hospital | 2 | 0 | 1 | 2018 |
| SciTech Development, LLC | For profit | 2 | 2 | 1 | 2020 |
| Beyond Drug Development | For profit | 1 | 0 | 1 | 2023 |
| Case Western Reserve University | Academic/Hospital | 1 | 0 | 1 | 2018 |
| Cystic Fibrosis Foundation Therapeutics | Academic/Hospital | 1 | 0 | 1 | 2018 |
| Island Pharmaceuticals | For profit | 1 | 1 | 1 | 2023 |
| Rush University | Academic/Hospital | 1 | 0 | 1 | 2020 |
| Scientia Clinical Research Limited Sydney | For profit | 1 | 0 | 1 | 2023 |
9 organizations
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