Hydroxytryptophan
Small moleculeexperimental
5-Hydroxytryptophan (5-HTP), used medically as oxitriptan, is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitter serotonin. — Wikipedia
Clinical trial activity
18 trials · 17 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
7
Phase 3
2
Phase 4
3
Earliest trial started Nov 1, 2000 (NCT00100464)
Timeline
2000s
- Jan 1, 2006
Earliest Phase 2 Sponsor(trial)
Indications
Approved for
Studied for
- Asthma · Phase 2
- Colitis, Ulcerative · Phase 2
- Crohn Disease · Phase 2
- Fatigue · Phase 2
- Fragile X Syndrome · Phase 2
- Major Depressive Disorder · Phase 4
- Obesity · Phase 2
- Prostatic Hyperplasia · Phase 2
- Remission Induction · Phase 2
- Sleep Apnea, Obstructive · Phase 4
- Spinal Cord Injuries · Phase 2/Phase 3
- Urination Disorders · Phase 2
Mechanism of action
- tryptophanSupplementation
tryptophan supplementation
Chemistry & pharmacology
Loading structure…
SMILES
N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O- Mol. weight
- 220.23 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- Wikipedia5-Hydroxytryptophan ↗
- ChEMBLCHEMBL350221 ↗
Also known as
- 5-hydroxy-l-tryptophan
- 5-hydroxy-l-tryptophan
- 5 hydroxy-tryptophan
- 5 hydroxy-tryptophan
- 5-hydroxytryptophan
- 5-hydroxytryptophan
- 5-hydroxytryptophan l-form
- 5-hydroxytryptophan l-form
- cincofarm
- cincofarm
- hydroxy-5 l-tryptophane
- hydroxy-5 l-tryptophane
- l-5-hydroxytryptophan
- l-5-hydroxytryptophan
- l-5-hydroxytryptophan
- levothym
- levothym
- levothym
- levotinine
- levotonine
- levotonine
- oxitriptan
- oxitriptan
- oxitriptan
- oxitriptan
- oxitriptan
- oxitriptan
- oxitriptan
- oxyfan
- pretonine
- tript-oh
- tript-oh
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05895747 | Phase 2 | Sep 1, 2023 | University of Utah |
| NCT05401032 | Phase 2 | Jun 30, 2022 | Clinical Academic Center, 2CA-Braga, Portugal |
| NCT05030129 | Phase 2 | Sep 15, 2021 | Rush University |
| NCT05216406 | N/A | Jan 1, 2021 | Nova Southeastern University |
| NCT04395183 | Phase 2 | Aug 1, 2020 | University of Utah |
| NCT04520178 | Phase 2/Phase 3 (Phase 3) | Jul 1, 2020 | University of Louisville |
| NCT04078724 | N/A | Oct 10, 2019 | National University of Singapore |
| NCT04160910 | Phase 2 | Sep 12, 2019 | Indiana University |
| NCT04000919 | Phase 2/Phase 3 (Phase 3) | Jun 19, 2019 | University of Louisville |
| NCT03574948 | Phase 2 | Sep 1, 2018 | Ghent University |
| NCT02922725 | Phase 4 | Nov 1, 2016 | University of Utah |
| NCT02356107 | Phase 4 | Apr 1, 2015 | University of Utah |
| NCT02187341 | N/A | Jun 1, 2014 | Benedictine University |
| NCT02689479 | N/A | May 1, 2013 | Karolinska Institute, National Institute of Allergy and Infectious Diseases (NIAID), Uppsala University |
| NCT02967354 | N/A | Jan 1, 2013 | Uppsala University |
| NCT00731003 | N/A | Apr 1, 2009 | Maastricht University, Top Institute Food and Nutrition |
| NCT00328913 | Phase 2 | Mar 1, 2006 | Laboratoire Oenobiol, TNO |
| NCT00100464 | Phase 4 | Nov 1, 2000 | Department of Veteran Affairs |
Showing 18 of 18 trials
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Organizations
Research & Development (17)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Utah | Academic/Hospital | 4 | 4 | 2 | 2015 |
| University of Louisville | Academic/Hospital | 2 | 2 | 1 | 2019 |
| Uppsala University | Academic/Hospital | 2 | 1 | 1 | 2013 |
| Benedictine University | Academic/Hospital | 1 | 1 | 1 | 2014 |
| Clinical Academic Center, 2CA-Braga, Portugal | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Department of Veteran Affairs | Government | 1 | 1 | 1 | 2000 |
| Ghent University | Academic/Hospital | 1 | 1 | 1 | 2018 |
| Indiana University | Academic/Hospital | 1 | 1 | 1 | 2019 |
| Karolinska Institute | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Laboratoire Oenobiol | For profit | 1 | 0 | 1 | 2006 |
| Maastricht University | Academic/Hospital | 1 | 1 | 1 | 2009 |
| National Institute of Allergy and Infectious Diseases (NIAID) | Government | 1 | 1 | 1 | 2013 |
| National University of Singapore | Academic/Hospital | 1 | 1 | 1 | 2019 |
| Nova Southeastern University | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Rush University | Academic/Hospital | 1 | 1 | 1 | 2021 |
| TNO | For profit | 1 | 1 | 1 | 2006 |
| Top Institute Food and Nutrition | Academic/Hospital | 1 | 0 | 1 | 2009 |
17 organizations
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