interferon alpha-1
Recombinant proteinexperimental
Interferon alpha-1 is a protein that in humans is encoded by the IFNA1 gene. — Wikipedia
Clinical trial activity
17 trials · 23 clinical orgs · 0 marketing orgs
Phase 1
5
Phase 2
9
Phase 3
3
Phase 4
4
Earliest trial started Sep 30, 2003 (NCT00178763)
Timeline
Indications
Approved for
Studied for
- COVID-19 · Phase 3
- Drug-Related Side Effects and Adverse Reactions · Phase 1/Phase 2
- Drugs, Investigational · Early Phase 1
- Hepatitis B, Chronic · Phase 4
- Herpes Zoster · Phase 2
- Leukemia, Myeloid · Phase 2
- Liver Cirrhosis · Phase 4
- Melanoma · Phase 2
- Myelodysplastic Syndromes · Phase 2
- Non-alcoholic Fatty Liver Disease · Phase 4
- Pancreatic Neoplasms · Phase 2
- Polycythemia Vera · Phase 3
- Respiratory Syncytial Virus Infections · Phase 3
- Thrombocytopenia · Phase 4
Mechanism of action
- Interferon alphaSupplementation
Interferon alpha supplementation
- Interferon alpha-17 (IFNA17) ↗
- Interferon alpha-4 (IFNA4) ↗
- Interferon alpha-14 (IFNA14) ↗
- Interferon alpha-6 (IFNA6) ↗
- Interferon alpha-8 (IFNA8) ↗
- Interferon alpha-5 (IFNA5) ↗
- Interferon alpha-10 (IFNA10) ↗
- Interferon alpha-2 (IFNA2) ↗
- Interferon alpha-1/13 (IFNA1; IFNA13) ↗
- Interferon alpha-7 (IFNA7) ↗
- Interferon alpha-21 (IFNA21) ↗
- Interferon alpha-16 (IFNA16) ↗
Chemistry & pharmacology
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaInterferon alpha-1 ↗
Also known as
- human interferon-alpha
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06363370 | Phase 3 | Mar 27, 2024 | Kexing Biopharm Co., Ltd. |
| NCT06212388 | Early Phase 1 (Phase 1) | Jan 24, 2024 | Beijing GD Initiative Cell Therapy Technology Co.，Ltd., Xijing Hospital |
| NCT06368882 | Phase 4 | Jan 1, 2024 | Wenzhou Medical University |
| NCT06130579 | Phase 2 | Dec 1, 2023 | Peking University |
| NCT06256627 | N/A | Jul 11, 2023 | Henan Medical University, Henan Provincial Cancer Hospital |
| NCT05539118 | Phase 1/Phase 2 (Phase 2) | Sep 30, 2022 | Xijing Hospital |
| NCT05492591 | Phase 2 | Aug 15, 2022 | China National Biotec Group Co., Ltd, Chinese Academy of Medical Sciences |
| NCT05395507 | Phase 4 | Jun 1, 2022 | Chinese Academy of Medical Sciences |
| NCT04640129 | Phase 4 | Nov 30, 2020 | Sun Yat-Sen University |
| NCT05639803 | Phase 1 | Jul 7, 2020 | Bengbu Medical College, China National Biotec Group Co., Ltd |
| NCT04293887 | Early Phase 1 (Phase 1) | Mar 1, 2020 | Huazhong University of Science and Technology |
| NCT04320238 | Phase 3 | Jan 21, 2020 | Jiao Tong University |
| NCT04116502 | Phase 3 | Oct 31, 2019 | MPN Voice, National Cancer Institute, France, Novartis, University of Birmingham, University of London, University of Paris |
| NCT04226950 | Phase 4 | Jul 20, 2019 | Chinese Academy of Medical Sciences |
| NCT03638375 | Phase 1/Phase 2 (Phase 2) | Jul 31, 2018 | Bristol-Myers Squibb, Leiden University |
| NCT01341158 | Phase 2 | Apr 1, 2011 | University of Tuebingen |
| NCT00178763 | Phase 2 | Sep 30, 2003 | University of Texas at Houston |
Showing 17 of 17 trials
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Organizations
Research & Development (23)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Chinese Academy of Medical Sciences | Academic/Hospital | 3 | 2 | 2 | 2019 |
| China National Biotec Group Co., Ltd | For profit | 2 | 2 | 2 | 2020 |
| Xijing Hospital | Academic/Hospital | 2 | 2 | 2 | 2022 |
| Beijing GD Initiative Cell Therapy Technology Co.，Ltd. | Government | 1 | 0 | 1 | 2024 |
| Bengbu Medical College | Academic/Hospital | 1 | 0 | 1 | 2020 |
| Bristol-Myers Squibb | For profit | 1 | 0 | 1 | 2018 |
| Henan Medical University | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Henan Provincial Cancer Hospital | Academic/Hospital | 1 | 0 | 1 | 2023 |
| Huazhong University of Science and Technology | Academic/Hospital | 1 | 1 | 1 | 2020 |
| Jiao Tong University | Academic/Hospital | 1 | 1 | 1 | 2020 |
| Kexing Biopharm Co., Ltd. | For profit | 1 | 1 | 1 | 2024 |
| Leiden University | Academic/Hospital | 1 | 1 | 1 | 2018 |
| MPN Voice | Academic/Hospital | 1 | 0 | 1 | 2019 |
| National Cancer Institute, France | Government | 1 | 0 | 1 | 2019 |
| Novartis | For profit | 1 | 0 | 1 | 2019 |
| Peking University | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Sun Yat-Sen University | Academic/Hospital | 1 | 1 | 1 | 2020 |
| University of Birmingham | Academic/Hospital | 1 | 1 | 1 | 2019 |
| University of London | Academic/Hospital | 1 | 0 | 1 | 2019 |
| University of Paris | Academic/Hospital | 1 | 0 | 1 | 2019 |
23 organizations
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