streptococcus pyogenes
Streptococcus pyogenes is a species of Gram-positive, aerotolerant bacteria in the genus Streptococcus. These bacteria are extracellular, and made up of non-motile and non-sporing cocci that tend to link in chains. They are clinically important for humans, as they are an infrequent, but usually pathogenic, part of the skin microbiota that can cause group A streptococcal infection. S. pyogenes is the predominant species harboring the Lancefield group A antigen, and is often called group A Streptococcus (GAS). However, both Streptococcus dysgalactiae and the Streptococcus anginosus group can possess group A antigen as well. Group A streptococci, when grown on blood agar, typically produce small (2–3 mm) zones of beta-hemolysis, a complete destruction of red blood cells. The name group A (beta-hemolytic) Streptococcus is thus also used. — Wikipedia
Clinical trial activity
3 trials · 19 clinical orgs · 0 marketing orgs
Earliest trial started Jun 27, 2018 (NCT03361163)
Timeline
2010s
- Jan 1, 2018
Earliest Phase 1 Sponsor(trial)
Indications
Mechanism of action
- Unspecified targetUnclear
unclear
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaStreptococcus pyogenes ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06992141 | Early Phase 1 (Phase 1) | Jul 24, 2025 | Duke University, Free University of Brussels, Leducq Foundation, Monash University, Murdoch University, National Health and Medical Research Council, Australia, University of Auckland, University of California, San Diego, University of Melbourne, University of Queensland, University of Wollongong |
| NCT03998592 | Phase 1 | Oct 31, 2019 | Butantan Institute, Fundação Butantan, University of Sao Paulo |
| NCT03361163 | Phase 1 | Jun 27, 2018 | Free University of Brussels, Griffith University, Murdoch University, National Health and Medical Research Council, Australia, Nucleus Network Ltd, Telethon Kids Institute, The Peter Doherty Institute, University of Auckland, University of Melbourne, University of Queensland, University of Tennessee, University of Wollongong |
Organizations
Research & Development (19)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Free University of Brussels | Academic/Hospital | 2 | 0 | 1 | 2018 |
| Murdoch University | Academic/Hospital | 2 | 2 | 1 | 2018 |
| National Health and Medical Research Council, Australia | Government | 2 | 0 | 1 | 2018 |
| University of Auckland | Academic/Hospital | 2 | 0 | 1 | 2018 |
| University of Melbourne | Academic/Hospital | 2 | 0 | 1 | 2018 |
| University of Queensland | Academic/Hospital | 2 | 0 | 1 | 2018 |
| University of Wollongong | Government | 2 | 0 | 1 | 2018 |
| Butantan Institute | Academic/Hospital | 1 | 1 | 1 | 2019 |
| Duke University | Academic/Hospital | 1 | 0 | 1 | 2025 |
| Fundação Butantan | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Griffith University | Academic/Hospital | 1 | 0 | 1 | 2018 |
| Leducq Foundation | Academic/Hospital | 1 | 0 | 1 | 2025 |
| Monash University | Academic/Hospital | 1 | 0 | 1 | 2025 |
| Nucleus Network Ltd | For profit | 1 | 0 | 1 | 2018 |
| Telethon Kids Institute | Academic/Hospital | 1 | 0 | 1 | 2018 |
| The Peter Doherty Institute | Academic/Hospital | 1 | 0 | 1 | 2018 |
| University of California, San Diego | Academic/Hospital | 1 | 0 | 1 | 2025 |
| University of Sao Paulo | Academic/Hospital | 1 | 0 | 1 | 2019 |
| University of Tennessee | Academic/Hospital | 1 | 0 | 1 | 2018 |