linerixibat
Small moleculeexperimental
Clinical trial activity
15 trials · 1 clinical orgs · 0 marketing orgs
Phase 1
8
Phase 2
6
Phase 3
2
Phase 4
0
Earliest trial started Jun 15, 2011 (NCT01416324)
Timeline
Indications
Mechanism of action
- Ileal bile acid transporterINHIBITOR
Ileal bile acid transporter inhibitor
- Unspecified targetUnclear
unclear
Chemistry & pharmacology
Loading structure…
SMILES
CCCC[C@]1(CC)CS(=O)(=O)c2cc(CNC(CC(=O)O)CC(=O)O)c(OC)cc2[C@@H](c2ccccc2)N1- Mol. weight
- 546.69 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL2387408 ↗
Also known as
- 3-((((3r,5r)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl)methyl)amino)pentanedioic acid
- gsk2230672
- gsk2330672
- gsk2330672
- gsk2330672
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05435170 | Phase 1 | Aug 11, 2022 | GlaxoSmithKline |
| NCT05393076 | Phase 1 | Jun 17, 2022 | GlaxoSmithKline |
| NCT05133830 | Phase 1 | Nov 23, 2021 | GlaxoSmithKline |
| NCT04950127 | Phase 3 | Aug 27, 2021 | GlaxoSmithKline |
| NCT04167358 | Phase 3 | Jan 10, 2020 | GlaxoSmithKline |
| NCT04053023 | Phase 1 | Aug 21, 2019 | GlaxoSmithKline |
| NCT03992014 | Phase 1 | Jul 1, 2019 | GlaxoSmithKline |
| NCT02966834 | Phase 2 | Jan 10, 2017 | GlaxoSmithKline |
| NCT02801981 | Phase 1 | Jun 1, 2016 | GlaxoSmithKline |
| NCT02202161 | Phase 2 | Aug 1, 2014 | GlaxoSmithKline |
| NCT01899703 | Phase 2 | Mar 1, 2014 | GlaxoSmithKline |
| NCT01929863 | Phase 2 | Aug 1, 2013 | GlaxoSmithKline |
| NCT01607385 | Phase 1 | May 18, 2012 | GlaxoSmithKline |
| NCT01416324 | Phase 1 | Jun 15, 2011 | GlaxoSmithKline |
| NCT05448170 | N/A | — | GlaxoSmithKline |
Showing 15 of 15 trials
Page 1 / 1
Organizations
Research & Development (1)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| GlaxoSmithKline | For profit | 15 | 15 | 4 | 2011 |
1 organizations
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