lauric acid
Lauric acid, or dodecanoic acid, is the main acid in coconut oil and in palm kernel oil, and is believed to have antimicrobial properties. The detected values of half maximal effective concentration (EC(50)) of lauric acid on P. acnes, S. aureus, and S. epidermidis growth indicate that P. acnes is the most sensitive to lauric acid among these bacteria. In addition, lauric acid did not induce cytotoxicity to human sebocytes. This data highlight the potential of using lauric acid as an alternative treatment for antibiotic therapy of acne vulgaris. Lauric acid is used in the manufacture of soaps, detergents, cosmetics, and lauryl alcohol. — NCATS
Clinical trial activity
6 trials · 6 clinical orgs · 0 marketing orgs
Earliest trial started Sep 1, 1996 (NCT00004690)
Timeline
Indications
Approved for
Mechanism of action
- excipientOTHER
excipient other
Chemistry & pharmacology
SMILES
CCCCCCCCCCCC(O)=O- Mol. weight
- 200.3178 g/mol
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaMonolaurin ↗
- NCATS1160N9NU9U ↗
- WikipediaLauric acid ↗
Also known as
- 1-dodecylglycerol
- 1-o-dodecylglycerol
- dodecanoic acid, monoester with 1,2,3-propanetriol
- glycerol monolaurate
- lauricidin
- monododecylglycerol
- monoglycerol laurate
- monolaurin
- monolaurin
- monolaurin
- rac-sn-1(3)-dodecylglycerol
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06046937 | Early Phase 1 (Phase 1) | Jun 1, 2023 | Victoriano Luna Medical Center |
| NCT05602324 | N/A | Oct 1, 2021 | University of British Columbia |
| NCT04292236 | N/A | Feb 22, 2019 | University of London |
| NCT02709005 | Phase 2 | Apr 14, 2016 | National Institute of Allergy and Infectious Diseases (NIAID) |
| NCT02772458 | N/A | Jun 30, 2015 | University of Nottingham |
| NCT00004690 | Phase 3 | Sep 1, 1996 | Cellegy Pharmaceuticals |
Organizations
Research & Development (6)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Cellegy Pharmaceuticals | For profit | 1 | 1 | 1 | 1996 |
| National Institute of Allergy and Infectious Diseases (NIAID) | Government | 1 | 1 | 1 | 2016 |
| University of British Columbia | Academic/Hospital | 1 | 1 | 1 | 2021 |
| University of London | Academic/Hospital | 1 | 1 | 1 | 2019 |
| University of Nottingham | Academic/Hospital | 1 | 1 | 1 | 2015 |
| Victoriano Luna Medical Center | Academic/Hospital | 1 | 1 | 1 | 2023 |