firibastat
Small moleculeexperimental
Clinical trial activity
11 trials · 9 clinical orgs · 0 marketing orgs
Phase 1
4
Phase 2
7
Phase 3
3
Phase 4
0
Earliest trial started Jul 1, 2010 (NCT00947661)
Timeline
Indications
Mechanism of action
- AminopeptidaseINHIBITOR
Aminopeptidase inhibitor
- Aminopeptidase N (ANPEP) ↗
- Puromycin-sensitive aminopeptidase (NPEPPS) ↗
- Aminopeptidase B (RNPEP) ↗
- Methionine aminopeptidase 1 (METAP1) ↗
- Leucyl-cystinyl aminopeptidase (LNPEP) ↗
- Aspartyl aminopeptidase (DNPEP) ↗
- Glutamyl aminopeptidase (ENPEP) ↗
- Xaa-Pro aminopeptidase 1 (XPNPEP1) ↗
- Cytosol aminopeptidase (LAP3) ↗
- Methionine aminopeptidase 2 (METAP2) ↗
- Xaa-Pro aminopeptidase 2 (XPNPEP2) ↗
- Endoplasmic reticulum aminopeptidase 2 (ERAP2) ↗
- Endoplasmic reticulum aminopeptidase 1 (ERAP1) ↗
- Aminopeptidase Q (LVRN) ↗
- Aminopeptidase O (AOPEP) ↗
- Methionine aminopeptidase 1D, mitochondrial (METAP1D) ↗
- Probable aminopeptidase NPEPL1 (NPEPL1) ↗
- Aminopeptidase RNPEPL1 (RNPEPL1) ↗
- Xaa-Pro aminopeptidase 3 (XPNPEP3) ↗
- Aminopeptidase N
- Xaa-Pro aminopeptidase 1
- Methionine aminopeptidase 1
- Methionine aminopeptidase 2
- Aminopeptidase B
- Cystinyl aminopeptidase
- Xaa-Pro aminopeptidase 2
- Aspartyl aminopeptidase
- Puromycin-sensitive aminopeptidase
- Aminopeptidase A
- Leucine aminopeptidase
- Endoplasmic reticulum aminopeptidase 2
- Endoplasmic reticulum aminopeptidase 1
- Aminopeptidase AINHIBITOR
Aminopeptidase A inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
N[C@@H](CCS(=O)(=O)O)CSSC[C@@H](N)CCS(=O)(=O)O- Mol. weight
- 368.52 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Prodrug
Sources
- ChEMBLCHEMBL4297511 ↗
Also known as
- qgc001
- sparc0912
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04857840 | Phase 3 | Aug 5, 2021 | Pharmaceutical Research Associates, Inc. (PRA), Quantum Genomics SA, University of Chicago |
| NCT04277884 | Phase 3 | Mar 1, 2020 | Quantum Genomics SA |
| NCT04792333 | Phase 1 | Sep 17, 2019 | Eurofins, Quantum Genomics SA |
| NCT03715998 | Phase 2 | Jun 4, 2019 | Quantum Genomics SA, Sorbonne University |
| NCT03714685 | Phase 1 | Feb 15, 2019 | Quantum Genomics SA, Quotient |
| NCT03198793 | Phase 2 | Oct 13, 2017 | Quantum Genomics SA, Tulane University |
| NCT02780180 | Phase 2 | Jun 1, 2016 | Quantum Genomics SA, University of Lorraine |
| NCT02322450 | Phase 2 | Jan 1, 2015 | Quantum Genomics SA |
| NCT01900184 | Phase 1 | Dec 1, 2012 | Quantum Genomics SA |
| NCT01900171 | Phase 1 | Feb 1, 2012 | Quantum Genomics SA |
| NCT00947661 | Phase 3 | Jul 1, 2010 | SPARC |
Showing 11 of 11 trials
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Organizations
Research & Development (9)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Quantum Genomics SA | For profit | 10 | 10 | 3 | 2012 |
| Eurofins | For profit | 1 | 0 | 1 | 2019 |
| Pharmaceutical Research Associates, Inc. (PRA) | For profit | 1 | 0 | 1 | 2021 |
| Quotient | For profit | 1 | 0 | 1 | 2019 |
| Sorbonne University | Academic/Hospital | 1 | 0 | 1 | 2019 |
| SPARC | For profit | 1 | 1 | 1 | 2010 |
| Tulane University | Academic/Hospital | 1 | 0 | 1 | 2017 |
| University of Chicago | Academic/Hospital | 1 | 0 | 1 | 2021 |
| University of Lorraine | Academic/Hospital | 1 | 0 | 1 | 2016 |
9 organizations
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