lactococcus lactis
Lactococcus lactis is a gram-positive bacterium used extensively in the production of buttermilk and cheese, but has also become famous as the first genetically modified organism to be used alive for the treatment of human disease. L. lactis cells are cocci that group in pairs and short chains, and, depending on growth conditions, appear ovoid with a typical length of 0.5 - 1.5 μm. L. lactis does not produce spores (nonsporulating) and are not motile (nonmotile). They have a homofermentative metabolism, meaning they produce lactic acid from sugars. They've also been reported to produce exclusive L-(+)-lactic acid. However, reported D-(−)-lactic acid can be produced when cultured at low pH. The capability to produce lactic acid is one of the reasons why L. lactis is one of the most important microorganisms in the dairy industry. Based on its history in food fermentation, L. lactis has generally recognized as safe (GRAS) status, with few case reports of it being an opportunistic pathogen. — Wikipedia
Clinical trial activity
12 trials · 25 clinical orgs · 0 marketing orgs
Earliest trial started Apr 14, 2015 (NCT03528707)
Timeline
No events for the selected filters.
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaLactococcus lactis ↗
Also known as
- lactococcus lactis subsp. lactis ll358
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06650644 | N/A | Oct 10, 2024 | KoBioLabs, Korea University, Kyung Hee University |
| NCT05800704 | N/A | Mar 10, 2023 | Cantonal Hospital Winterthur, Luzerner Kantonsspital, Stadtspital Zürich, University of Basel, University of Bern, University of Zurich |
| NCT05632341 | N/A | Dec 20, 2022 | Green Cross Corporation |
| NCT04997057 | N/A | Sep 15, 2021 | CEN Biotech, Hopital Antoine Beclere, Pileje |
| NCT04659408 | N/A | Mar 1, 2021 | Swiss Paraplegic Centre Nottwil |
| NCT03959722 | N/A | Oct 31, 2019 | Hogeschool Leiden, University of Applied Sciences, Leiden University, University of Amsterdam, Wageningen University, Winclove Bio Industries BV |
| NCT04089280 | N/A | Oct 16, 2018 | Sanprobi Sp. z o.o., Silesian University of Medicine |
| NCT04201938 | N/A | Feb 1, 2018 | Bogomolets National Medical University, Taras Shevchenko National University of Kyiv |
| NCT03220802 | N/A | Sep 22, 2017 | Medical University of Graz |
| NCT03300440 | N/A | Jun 21, 2017 | Medical University of Graz |
| NCT03066921 | N/A | Jun 1, 2016 | Tung's Taiching MetroHarbor Hospital |
| NCT03528707 | N/A | Apr 14, 2015 | Bogomolets National Medical University |
Organizations
Research & Development (25)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Bogomolets National Medical University | Academic/Hospital | 2 | 2 | 1 | 2015 |
| Medical University of Graz | Academic/Hospital | 2 | 2 | 1 | 2017 |
| Cantonal Hospital Winterthur | Academic/Hospital | 1 | 0 | 1 | 2023 |
| CEN Biotech | For profit | 1 | 1 | 1 | 2021 |
| Green Cross Corporation | For profit | 1 | 1 | 1 | 2022 |
| Hogeschool Leiden, University of Applied Sciences | Academic/Hospital | 1 | 1 | 1 | 2019 |
| Hopital Antoine Beclere | Academic/Hospital | 1 | 0 | 1 | 2021 |
| KoBioLabs | For profit | 1 | 0 | 1 | 2024 |
| Korea University | Academic/Hospital | 1 | 0 | 1 | 2024 |
| Kyung Hee University | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Leiden University | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Luzerner Kantonsspital | Academic/Hospital | 1 | 0 | 1 | 2023 |
| Pileje | Academic/Hospital | 1 | 0 | 1 | 2021 |
| Sanprobi Sp. z o.o. | For profit | 1 | 0 | 1 | 2018 |
| Silesian University of Medicine | Academic/Hospital | 1 | 1 | 1 | 2018 |
| Stadtspital Zürich | Academic/Hospital | 1 | 0 | 1 | 2023 |
| Swiss Paraplegic Centre Nottwil | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Taras Shevchenko National University of Kyiv | Academic/Hospital | 1 | 0 | 1 | 2018 |
| Tung's Taiching MetroHarbor Hospital | Academic/Hospital | 1 | 1 | 1 | 2016 |
| University of Amsterdam | Academic/Hospital | 1 | 0 | 1 | 2019 |