levcromakalim
Small moleculeexperimental
Cromakalim (INN) is a potassium channel-opening vasodilator. The active isomer is levcromakalim. It acts on ATP-sensitive potassium channels and so causes membrane hyperpolarization. It can be used to treat hypertension as it will relax vascular smooth muscle to lower blood pressure. Hyperpolarisation of smooth muscle cell membranes pulls their membrane potential away from the threshold, so making it more difficult to excite them and thereby cause relaxation. — Wikipedia
Clinical trial activity
11 trials · 2 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Earliest trial started May 24, 2017 (NCT03228355)
Timeline
No events for the selected filters.
Chemistry & pharmacology
Loading structure…
SMILES
CC1(C)Oc2ccc(C#N)cc2[C@@H](N2CCCC2=O)[C@@H]1O- Mol. weight
- 286.33 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaCromakalim ↗
- ChEMBLCHEMBL100 ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05889442 | N/A | Mar 9, 2023 | Novartis, University of Copenhagen |
| NCT05565001 | N/A | Sep 1, 2022 | University of Copenhagen |
| NCT05243953 | N/A | Mar 21, 2022 | University of Copenhagen |
| NCT05211050 | N/A | Feb 15, 2022 | University of Copenhagen |
| NCT04905654 | N/A | Sep 29, 2021 | University of Copenhagen |
| NCT05093582 | N/A | Jun 4, 2021 | University of Copenhagen |
| NCT04012047 | N/A | Jul 10, 2019 | University of Copenhagen |
| NCT03886922 | N/A | Apr 1, 2019 | University of Copenhagen |
| NCT03726242 | N/A | Nov 1, 2018 | University of Copenhagen |
| NCT03609008 | N/A | Jun 26, 2018 | University of Copenhagen |
| NCT03228355 | N/A | May 24, 2017 | University of Copenhagen |
Showing 11 of 11 trials
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Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Copenhagen | Academic/Hospital | 11 | 11 | 1 | 2017 |
| Novartis | For profit | 1 | 0 | 1 | 2023 |
2 organizations
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