zilucoplan
Trade name: ZILBRYSQ
Small moleculeapprovedOrphan Drug FDA
Approved
Oct 17, 2023
Clinical trial activity
18 trials · 6 clinical orgs · 1 marketing orgs
Phase 1
2
Phase 2
13
Phase 3
10
Phase 4
0
Earliest trial started Feb 1, 2017 (NCT03030183)
Timeline
Indications
Approved for
Mechanism of action
- Complement C5BINDING AGENT
Complement C5 binding agent
- Complement C5INHIBITOR
C5 inhibitor
Approval history
- approvedOct 17, 2023
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Availability
- Prescription Only
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL5315048 ↗
- ChEMBLCHEMBL4298207 ↗
Also known as
- ra101495
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07215949 | Phase 3 | Dec 1, 2025 | Ohio State University, UCB |
| NCT06961747 | Phase 1 | Jul 9, 2025 | UCB |
| NCT06435312 | Phase 3 | Oct 28, 2024 | UCB |
| NCT06471361 | Phase 3 | Aug 27, 2024 | UCB |
| NCT06511076 | Phase 1 | Aug 5, 2024 | UCB |
| NCT06055959 | Phase 2/Phase 3 (Phase 3) | Jan 31, 2024 | UCB |
| NCT05514873 | Phase 3 | Oct 31, 2022 | UCB |
| NCT04590586 | Phase 3 | Nov 24, 2020 | Amgen |
| NCT04436497 | Phase 2/Phase 3 (Phase 3) | Jun 30, 2020 | Harvard University, Ra Pharmaceuticals |
| NCT04297683 | Phase 2/Phase 3 (Phase 3) | May 31, 2020 | Harvard University |
| NCT04382755 | Phase 2 | May 31, 2020 | Ghent University, UCB |
| NCT04225871 | Phase 3 | Jan 31, 2020 | Ra Pharmaceuticals |
| NCT04025632 | Phase 2 | Nov 30, 2019 | Ra Pharmaceuticals |
| NCT04115293 | Phase 3 | Oct 1, 2019 | Ra Pharmaceuticals |
| NCT03315130 | Phase 2 | Oct 11, 2017 | Ra Pharmaceuticals |
| NCT03225287 | Phase 2 | Jul 17, 2017 | Ra Pharmaceuticals |
| NCT03078582 | Phase 2 | Mar 1, 2017 | Ra Pharmaceuticals |
| NCT03030183 | Phase 2 | Feb 1, 2017 | Ra Pharmaceuticals |
Showing 18 of 18 trials
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Organizations
Research & Development (6)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Ra Pharmaceuticals | For profit | 8 | 7 | 2 | 2017 |
| UCB | For profit | 8 | 6 | 3 | 2020 |
| Harvard University | Academic/Hospital | 2 | 2 | 1 | 2020 |
| Amgen | For profit | 1 | 1 | 1 | 2020 |
| Ghent University | Academic/Hospital | 1 | 1 | 1 | 2020 |
| Ohio State University | Academic/Hospital | 1 | 1 | 1 | 2025 |
6 organizations
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