thyroxine
Small moleculeexperimental
Thyroid hormones are two hormones produced and released by the thyroid gland, triiodothyronine (T3) and thyroxine (T4). They are tyrosine-based hormones that are primarily responsible for regulation of metabolism. T3 and T4 are partially composed of iodine, derived from food. A deficiency of iodine leads to decreased production of T3 and T4, enlarges the thyroid tissue and will cause the disease known as simple goitre. — Wikipedia
Clinical trial activity
9 trials · 11 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
6
Phase 3
2
Phase 4
0
Earliest trial started Sep 1, 2016 (NCT03712683)
Timeline
Indications
Studied for
- Acupuncture · Phase 2
- Brain Death · Phase 3
- General Surgery · Phase 2
- Heart Failure · Phase 3
- Hypothyroidism · Phase 2/Phase 3
- Infant, Premature, Diseases · Phase 2
- Infertility · Phase 2
- Menstruation Disturbances · Phase 2
- Polycystic Ovary Syndrome · Phase 2
- Recurrence · Phase 2
- Thyroid Diseases · Phase 2
- Thyroid Gland · Phase 2
- Thyroid Hormones · Phase 2
- Thyroiditis, Autoimmune · Phase 2
- Thyroid Neoplasms · Phase 2
Mechanism of action
- Unspecified targetUnclear
unclear
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaThyroid hormones ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06345339 | Phase 2/Phase 3 (Phase 3) | Apr 26, 2024 | AbbVie |
| NCT06087068 | Phase 2 | Aug 1, 2022 | Chinese Academy of Medical Sciences |
| NCT05421468 | N/A | Mar 14, 2022 | King Abdullah Medical City |
| NCT05804149 | Phase 2 | Aug 30, 2020 | Cairo University |
| NCT04415658 | Phase 3 | Jun 15, 2020 | Washington University in St. Louis |
| NCT04124705 | Phase 2 | Oct 14, 2019 | Allergan |
| NCT03390530 | Phase 2 | Jan 1, 2019 | University of Pittsburgh, Washington University in St. Louis, Westchester Medical Center, Yeshiva University |
| NCT03289403 | Phase 2 | Sep 7, 2017 | Aljazeera Hospital |
| NCT03712683 | N/A | Sep 1, 2016 | Hawler Medical University |
Showing 9 of 9 trials
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Organizations
Research & Development (11)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Washington University in St. Louis | Academic/Hospital | 2 | 1 | 2 | 2019 |
| AbbVie | For profit | 1 | 1 | 1 | 2024 |
| Aljazeera Hospital | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Allergan | For profit | 1 | 1 | 1 | 2019 |
| Cairo University | Academic/Hospital | 1 | 1 | 1 | 2020 |
| Chinese Academy of Medical Sciences | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Hawler Medical University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| King Abdullah Medical City | Academic/Hospital | 1 | 1 | 1 | 2022 |
| University of Pittsburgh | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Westchester Medical Center | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Yeshiva University | Academic/Hospital | 1 | 1 | 1 | 2019 |
11 organizations
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