revakinagene taroretcel

Trade name: Encelto

Recombinant proteinapprovedOrphan Drug FDA

Approved

Mar 5, 2025

Ciliary neurotrophic factor is a protein that in humans is encoded by the CNTF gene. — Wikipedia

Clinical trial activity

18 trials · 11 clinical orgs · 0 marketing orgs

Phase 1
5
Phase 2
13
Phase 3
3
Phase 4
1

Earliest trial started Jun 1, 2003 (NCT00063765)

Timeline

2000s

  1. Jan 1, 2003

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2007

    Earliest Phase 2 Sponsor(trial)

2010s

  1. Jul 24, 2012

    Orphan Drug Designation

  2. Jan 1, 2017

    Earliest Phase 3 Sponsor(trial)

2020s

  1. Mar 5, 2025

    Earliest FDA Approval

Indications

Approved for

Mechanism of action

Approval history

  • approvedMar 5, 2025

Chemistry & pharmacology

Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Multi-specific
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • ciliary neurotrophic factor
  • ciliary neurotrophic factor
  • ciliary neurotrophic factor (human)
  • human ciliary neurotrophic factor
  • human cntf
  • nt-501

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06971939Phase 4Aug 15, 2025Neurotech Pharmaceuticals
NCT06397131Phase 3Apr 1, 2025Neurotech Pharmaceuticals
NCT04729972Phase 2Mar 1, 2021Neurotech Pharmaceuticals, The EMMES Corporation, The Lowy Medical Research Institute Limited
NCT04577300Phase 2Oct 15, 2020Stanford University
NCT03319849Phase 3Feb 6, 2018National Eye Institute (NEI), Neurotech Pharmaceuticals
NCT03316300Phase 3Nov 24, 2017National Eye Institute (NEI), Neurotech Pharmaceuticals
NCT03071965Phase 2May 12, 2017Neurotech Pharmaceuticals
NCT02862938Phase 2Jun 1, 2016Stanford University
NCT01949324Phase 2Apr 1, 2014Duke University, Neurotech Pharmaceuticals, The EMMES Corporation, The Lowy Medical Research Institute Limited
NCT01648452Phase 1/Phase 2 (Phase 2)Jul 1, 2012National Eye Institute (NEI), National Institutes of Health (NIH)
NCT01530659Phase 2Jan 1, 2012Food and Drug Administration, Neurotech Pharmaceuticals, University of California, San Francisco
NCT01327911Phase 1May 1, 2011Neurotech Pharmaceuticals, Neurotech USA, The Lowy Medical Research Institute Limited
NCT01411657Phase 1Apr 1, 2011Stanford University
NCT01408472Phase 1Apr 1, 2011Stanford University, University of Miami
NCT00447954Phase 2Jan 1, 2007Neurotech Pharmaceuticals
NCT00447993Phase 2Jan 1, 2007Neurotech Pharmaceuticals
NCT00447980Phase 2Jan 1, 2007Neurotech Pharmaceuticals
NCT00063765Phase 1Jun 1, 2003National Eye Institute (NEI)
Showing 18 of 18 trials
Page 1 / 1

Organizations

Research & Development (11)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Neurotech PharmaceuticalsFor profit121242007
National Eye Institute (NEI)Government4232003
Stanford UniversityAcademic/Hospital4422011
The Lowy Medical Research Institute LimitedAcademic/Hospital3022011
The EMMES CorporationFor profit2012014
Duke UniversityAcademic/Hospital1012014
Food and Drug AdministrationGovernment1012012
National Institutes of Health (NIH)Government1012012
Neurotech USAFor profit1012011
University of California, San FranciscoAcademic/Hospital1012012
University of MiamiAcademic/Hospital1012011
11 organizations
Page 1 / 1