phosphatidylserine
Small moleculeexperimental
DB00144 (1-propionyl-2-butyl phosphatidylserine) is a phosphatidylserine derivative. It consists of a propionic and butyric acid residues attached in ester linkage to the first and second carbon of glycerol and serine attached through a phosphodiester linkage to the third carbon of the glycerol. DB00144 is not found in natural sources of phosphatidylserine, which contain fatty acids with a length of 20-22 carbon atoms. DB00144 was detected as one of the cellular metabolites in murine myocardium. — NCATS
Clinical trial activity
13 trials · 14 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
5
Phase 3
1
Phase 4
2
Earliest trial started Jul 1, 2004 (NCT00382616)
Timeline
Indications
Approved for
Mechanism of action
- Unspecified targetUnclear
Unclear
Chemistry & pharmacology
Loading structure…
SMILES
CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC- Mol. weight
- 792.0749 g/mol
- Lipinski Ro5
- 2 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaEnzymotec ↗
- NCATS394XK0IH40 ↗
- ChEMBLCHEMBL4297669 ↗
- WikipediaPhosphatidylserine ↗
Also known as
- phosphatidyl-l-serine
- phosphatidyl-l-serine
- phosphatidylserine
- phosphatidylserine
- phosphatidylserine
- phosphatidyl serine
- phosphatidyl serine
- phosphatidylserine, dha, and epa
- ps
- ps
- ptd-l-ser
- ptd-l-ser
- vayarin
- vayarin
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04920305 | N/A | Jan 1, 2022 | Air Force Military Medical University, China, Fengdong New Town Elderlywelfare Service Center, Jiao Tong University |
| NCT04967404 | N/A | Jul 15, 2021 | St Mary's University College |
| NCT04557228 | N/A | Jul 1, 2021 | University of Missouri |
| NCT05177978 | N/A | Nov 2, 2020 | Northumbria University |
| NCT03228550 | Phase 2 | Feb 26, 2017 | Bournemouth University, Efamol Ltd, Sylvia Waddilove Foundation |
| NCT03115671 | N/A | Nov 30, 2016 | Government of Singapore |
| NCT02348073 | Phase 3 | Mar 1, 2015 | University of Lyon |
| NCT02211560 | N/A | Sep 30, 2014 | Enzymotec |
| NCT02276716 | Phase 2 | Nov 1, 2011 | New York University |
| NCT00736034 | Phase 4 | Sep 1, 2008 | Enzymotec, Tel Aviv University |
| NCT00700323 | Phase 2 | Jul 1, 2008 | Enzymotec, Tel Aviv University |
| NCT00437983 | Phase 4 | Apr 1, 2007 | Enzymotec, Tel Aviv University |
| NCT00382616 | Phase 2 | Jul 1, 2004 | Tel Aviv University |
Showing 13 of 13 trials
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Organizations
Research & Development (14)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Enzymotec | For profit | 4 | 3 | 3 | 2007 |
| Tel Aviv University | Academic/Hospital | 4 | 2 | 2 | 2004 |
| Air Force Military Medical University, China | Academic/Hospital | 1 | 0 | 1 | 2022 |
| Bournemouth University | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Efamol Ltd | For profit | 1 | 0 | 1 | 2017 |
| Fengdong New Town Elderlywelfare Service Center | Academic/Hospital | 1 | 0 | 1 | 2022 |
| Government of Singapore | Government | 1 | 1 | 1 | 2016 |
| Jiao Tong University | Academic/Hospital | 1 | 1 | 1 | 2022 |
| New York University | Academic/Hospital | 1 | 1 | 1 | 2011 |
| Northumbria University | Academic/Hospital | 1 | 1 | 1 | 2020 |
| St Mary's University College | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Sylvia Waddilove Foundation | Academic/Hospital | 1 | 0 | 1 | 2017 |
| University of Lyon | Academic/Hospital | 1 | 1 | 1 | 2015 |
| University of Missouri | Academic/Hospital | 1 | 1 | 1 | 2021 |
14 organizations
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