lycopene
Lycopene is the fat-soluble pigment that gives tomatoes, watermelon, pink grapefruit, and other foods their red color. Bioavailability of lycopene is enhanced in the presence of lipids and thermal processing. Lycopene accounts for about 50% of the carotenoids found in human serum and is among the major carotenoids present in human milk. The antioxidant activity of lycopene and its use in cancer prevention and cardiovascular disease have been widely documented. The scientific literature documents some adverse reactions, such as diarrhea, dyspepsia, gas, nausea, and vomiting. One trial documented a cancer-related hemorrhage in a patient taking lycopene, although causality is unclear. Lycopene interacts with some cancer chemotherapy agents, as well as with ciprofloxacin and olestra. — NCATS
Clinical trial activity
14 trials · 21 clinical orgs · 0 marketing orgs
Earliest trial started Feb 1, 2010 (NCT01100385)
Timeline
2010s
- Jan 1, 2018
Earliest Phase 2 Sponsor(trial)
Indications
Mechanism of action
- Unspecified targetUnclear
unclear
Chemistry & pharmacology
SMILES
CC(C)=CCC\C(C)=C\C=C\C(C)=C\C=C\C(C)=C\C=C\C=C(C)\C=C\C=C(C)\C=C\C=C(/C)CCC=C(C)C- Mol. weight
- 536.8726 g/mol
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaLycopene ↗
- NCATSSB0N2N0WV6 ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07120035 | N/A | Mar 27, 2024 | Baylor University, East Carolina University, University of Minnesota |
| NCT05671562 | N/A | May 3, 2023 | Manchester Metropolitan University, National Health Service, United Kingdom, Sheffield Hallam University |
| NCT05328388 | N/A | Jan 1, 2022 | LycoRed Ltd. |
| NCT04418635 | N/A | Jun 4, 2020 | Acrobio Healthcare Inc., Chang Gung University |
| NCT03783013 | N/A | Apr 22, 2019 | United States Department of Agriculture |
| NCT03964935 | Phase 2 | Dec 1, 2018 | University of Baghdad |
| NCT03772808 | N/A | Nov 16, 2018 | LycoRed Ltd., Sprim Consulting |
| NCT04652739 | Phase 2/Phase 3 (Phase 3) | Oct 1, 2018 | Alexandria University |
| NCT03825042 | N/A | Jan 23, 2018 | Menarini Group |
| NCT03463967 | N/A | Oct 31, 2016 | University of Naples Frederico II |
| NCT03820245 | N/A | Aug 24, 2016 | Universidade Federal de Santa Maria |
| NCT01102504 | N/A | Aug 1, 2015 | University of Cambridge |
| NCT03492593 | N/A | Sep 30, 2014 | Aix-University of Marseille, Government of France, University of Avignon |
| NCT01100385 | N/A | Feb 1, 2010 | Cambridge Theranostics Ltd, University of Cambridge |
Organizations
Research & Development (21)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| LycoRed Ltd. | For profit | 2 | 2 | 1 | 2018 |
| University of Cambridge | Academic/Hospital | 2 | 2 | 1 | 2010 |
| Acrobio Healthcare Inc. | For profit | 1 | 1 | 1 | 2020 |
| Aix-University of Marseille | Academic/Hospital | 1 | 0 | 1 | 2014 |
| Alexandria University | Academic/Hospital | 1 | 1 | 1 | 2018 |
| Baylor University | Academic/Hospital | 1 | 0 | 1 | 2024 |
| Cambridge Theranostics Ltd | For profit | 1 | 0 | 1 | 2010 |
| Chang Gung University | Academic/Hospital | 1 | 0 | 1 | 2020 |
| East Carolina University | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Government of France | Government | 1 | 1 | 1 | 2014 |
| Manchester Metropolitan University | Academic/Hospital | 1 | 0 | 1 | 2023 |
| Menarini Group | For profit | 1 | 1 | 1 | 2018 |
| National Health Service, United Kingdom | Government | 1 | 0 | 1 | 2023 |
| Sheffield Hallam University | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Sprim Consulting | For profit | 1 | 0 | 1 | 2018 |
| United States Department of Agriculture | Government | 1 | 1 | 1 | 2019 |
| Universidade Federal de Santa Maria | Academic/Hospital | 1 | 1 | 1 | 2016 |
| University of Avignon | Academic/Hospital | 1 | 0 | 1 | 2014 |
| University of Baghdad | Academic/Hospital | 1 | 1 | 1 | 2018 |
| University of Minnesota | Academic/Hospital | 1 | 0 | 1 | 2024 |