antithrombin (Recombinant)
Trade name: ATryn
Approved
Feb 6, 2009
ATryn is the brand name of the anticoagulant antithrombin manufactured by the Massachusetts-based U.S. company rEVO Biologics. It is made from the milk of goats that have been genetically modified to produce human antithrombin, a plasma protein with anticoagulant properties. Microinjection was used to insert human antithrombin genes into the cell nucleus of their embryos. ATryn is the first medicine produced using genetically engineered animals. GTC states that one genetically modified goat can produce the same amount of antithrombin in a year as 90,000 blood donations. GTC chose goats for the process because they reproduce more rapidly than cattle and produce more protein than rabbits or mice. — Wikipedia
Clinical trial activity
1 trials · 1 clinical orgs · 2 marketing orgs
Earliest trial started Jun 30, 2024 (NCT06096116)
Timeline
2000s
- Dec 7, 2007
Orphan Drug Designation
- Feb 6, 2009
GTC Nutrition — Earliest FDA Approval
- Feb 6, 2009
GTC Nutrition — NDA Organization
- Feb 6, 2009
LFB Biotechnologies, SAS — NDA Secondary Org
2020s
- Jan 1, 2024
Earliest Phase 3 Sponsor(trial)
Indications
Approved for
Studied for
Mechanism of action
- Tumor necrosis factor ligand superfamily member 4Supplementation
TNFSF4 supplementation
Approval history
- approvedFeb 6, 2009
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaATryn ↗
- ChEMBLCHEMBL1201554 ↗
Also known as
- antithrombin iii,recombinant
- antithrombin iii, recombinant
- antithrombin (recombinant)
- atryn
- atryn
- recombinant antithrombin
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06096116 | Phase 3 | Jun 30, 2024 | Octapharma |
Organizations
Research & Development (1)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Octapharma | For profit | 1 | 1 | 1 | 2024 |
Marketing (2)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| GTC Nutrition | For profit | NDA | Feb 6, 2009 |
| LFB Biotechnologies, SAS | For profit | NDA2 | Feb 6, 2009 |