cg-200745
Small moleculeexperimental
Clinical trial activity
6 trials · 7 clinical orgs · 0 marketing orgs
Phase 1
6
Phase 2
3
Phase 3
0
Phase 4
0
Earliest trial started Sep 1, 2010 (NCT01226407)
Timeline
2010s
- Jan 1, 2010
Earliest Phase 1 Sponsor(trial)
Indications
Mechanism of action
- Histone deacetylase 2INHIBITOR
HDAC2 inhibitor
- Histone deacetylase 1INHIBITOR
HDAC1 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CN(C)CCCNC(=O)/C(=C/CCCCC(=O)NO)COc1cccc2ccccc12- Mol. weight
- 427.55 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL4297366 ↗
Also known as
- cg200745
- cg200745
- cg200745
- cg-200745
- n1-(3-(dimethylamino)propyl)-n8-hydroxy-2-((naphthalene-1-loxy)methyl)oct-2-enediamide
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05716919 | Phase 1 | Mar 9, 2023 | Machaon Biotherapeutics |
| NCT05249101 | Phase 1/Phase 2 (Phase 2) | Jul 1, 2022 | CG Pharmaceuticals, Inc, University of California, San Francisco |
| NCT05345912 | Phase 1 | Dec 16, 2019 | CrystalGenomics, Inc., Seoul National University |
| NCT02737462 | Phase 1/Phase 2 (Phase 2) | Jun 1, 2016 | CrystalGenomics, Inc., University of Ulsan |
| NCT02737228 | Phase 1/Phase 2 (Phase 2) | Mar 1, 2016 | CrystalGenomics, Inc., Yonsei University |
| NCT01226407 | Phase 1 | Sep 1, 2010 | CrystalGenomics, Inc., University of Ulsan |
Showing 6 of 6 trials
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Organizations
Research & Development (7)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| CrystalGenomics, Inc. | For profit | 4 | 4 | 2 | 2010 |
| University of Ulsan | Academic/Hospital | 2 | 0 | 2 | 2010 |
| CG Pharmaceuticals, Inc | For profit | 1 | 1 | 1 | 2022 |
| Machaon Biotherapeutics | For profit | 1 | 1 | 1 | 2023 |
| Seoul National University | Academic/Hospital | 1 | 0 | 1 | 2019 |
| University of California, San Francisco | Academic/Hospital | 1 | 0 | 1 | 2022 |
| Yonsei University | Academic/Hospital | 1 | 0 | 1 | 2016 |
7 organizations
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