tempol
Small moleculeexperimental
4-Hydroxy-TEMPO or TEMPOL, formally 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl, is a heterocyclic compound. Like the related TEMPO, it is used as a catalyst and chemical oxidant by virtue of being a stable aminoxyl radical. Its major appeal over TEMPO is that it is less expensive, being produced from triacetone amine, which is itself made via the condensation of acetone and ammonia. This makes it economically viable on an industrial scale. — Wikipedia
Clinical trial activity
8 trials · 5 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
3
Phase 3
1
Phase 4
0
Earliest trial started Sep 7, 2016 (NCT03680638)
Timeline
Indications
Mechanism of action
- Superoxide dismutaseACTIVATOR
SOD1 activator
Chemistry & pharmacology
Loading structure…
SMILES
CC1(C)CC(O)CC(C)(C)N1[O]- Mol. weight
- 172.25 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- Wikipedia4-Hydroxy-TEMPO ↗
- ChEMBLCHEMBL607023 ↗
Also known as
- tempol
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04729595 | Phase 2/Phase 3 (Phase 3) | Sep 1, 2021 | Adamis Pharmaceuticals Corporation |
| NCT04874506 | Phase 2 | Jun 1, 2021 | Georgetown University, Matrix Biomed, Inc. |
| NCT04876755 | Phase 2 | May 30, 2021 | Matrix Biomed, Inc. |
| NCT03480971 | Phase 2 | Oct 31, 2018 | Matrix Biomed, Inc., University of Maryland |
| NCT03680404 | Phase 1 | Oct 1, 2018 | University of Texas, Arlington |
| NCT03680638 | Phase 1 | Sep 7, 2016 | University of Texas, Arlington |
| NCT04337099 | N/A | — | Matrix Biomed, Inc. |
| NCT05491928 | N/A | — | Matrix Biomed, Inc. |
Showing 8 of 8 trials
Page 1 / 1
Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Matrix Biomed, Inc. | For profit | 5 | 5 | 2 | 2018 |
| University of Texas, Arlington | Academic/Hospital | 2 | 2 | 1 | 2016 |
| Adamis Pharmaceuticals Corporation | For profit | 1 | 1 | 1 | 2021 |
| Georgetown University | Academic/Hospital | 1 | 0 | 1 | 2021 |
| University of Maryland | Academic/Hospital | 1 | 0 | 1 | 2018 |
5 organizations
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