proline

Small moleculeexperimental

Proline (symbol Pro or P) is an organic acid classed as a proteinogenic amino acid (used in the biosynthesis of proteins), although it does not contain the amino group -NH2 but is rather a secondary amine. The secondary amine nitrogen is in the protonated form (NH2+) under biological conditions, while the carboxyl group is in the deprotonated −COO− form. The "side chain" from the α carbon connects to the nitrogen forming a pyrrolidine loop, classifying it as a aliphatic amino acid. It is non-essential in humans, meaning the body can synthesize it from the non-essential amino acid L-glutamate. It is encoded by all the codons starting with CC (CCU, CCC, CCA, and CCG). — Wikipedia

Clinical trial activity

2 trials · 2 clinical orgs · 0 marketing orgs

Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0

Earliest trial started Sep 30, 2007 (NCT01912235)

Timeline

No events for the selected filters.

Chemistry & pharmacology

Loading structure…

SMILES

O=C(O)[C@@H]1CCCN1
Mol. weight
115.13 g/mol
Lipinski Ro5
Pass
Rule of 3
Yes
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • l-proline
  • proline
  • proline
  • proline
  • proline
  • proline
  • proline
  • proline
  • proline, dl-

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT03826914N/ANov 6, 2018University of Manitoba
NCT01912235N/ASep 30, 2007University of Toronto
Showing 2 of 2 trials
Page 1 / 1

Organizations

Research & Development (2)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
University of ManitobaAcademic/Hospital1112018
University of TorontoAcademic/Hospital1112007
2 organizations
Page 1 / 1