proline
Proline (symbol Pro or P) is an organic acid classed as a proteinogenic amino acid (used in the biosynthesis of proteins), although it does not contain the amino group -NH2 but is rather a secondary amine. The secondary amine nitrogen is in the protonated form (NH2+) under biological conditions, while the carboxyl group is in the deprotonated −COO− form. The "side chain" from the α carbon connects to the nitrogen forming a pyrrolidine loop, classifying it as a aliphatic amino acid. It is non-essential in humans, meaning the body can synthesize it from the non-essential amino acid L-glutamate. It is encoded by all the codons starting with CC (CCU, CCC, CCA, and CCG). — Wikipedia
Clinical trial activity
2 trials · 2 clinical orgs · 0 marketing orgs
Earliest trial started Sep 30, 2007 (NCT01912235)
Timeline
No events for the selected filters.
Chemistry & pharmacology
SMILES
O=C(O)[C@@H]1CCCN1- Mol. weight
- 115.13 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaProline ↗
- ChEMBLCHEMBL72275 ↗
- ChEMBLCHEMBL54922 ↗
Also known as
- l-proline
- proline
- proline
- proline
- proline
- proline
- proline
- proline
- proline, dl-
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03826914 | N/A | Nov 6, 2018 | University of Manitoba |
| NCT01912235 | N/A | Sep 30, 2007 | University of Toronto |
Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Manitoba | Academic/Hospital | 1 | 1 | 1 | 2018 |
| University of Toronto | Academic/Hospital | 1 | 1 | 1 | 2007 |