dextrothyroxine
Trade name: choloxin
Small moleculeapproved
Approved
Apr 14, 1967
Dextrothyroxine is a dextrorotary isomer of thyroxine. It saw research as a cholesterol-lowering drug but was pulled due to cardiac side-effects. It increases hepatic lipase which in turn improves utilization of triglycerides and decreases levels of lipoprotein(a) in blood serum. — Wikipedia
Clinical trial activity
10 trials · 13 clinical orgs · 1 marketing orgs
Phase 1
0
Phase 2
2
Phase 3
2
Phase 4
2
Earliest trial started Apr 1, 1965 (NCT00000482)
Timeline
Indications
Approved for
Mechanism of action
- UnclearUnclear
Unclear unclear
Approval history
- approvedPriority reviewApr 14, 1967
Chemistry & pharmacology
Loading structure…
SMILES
N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O- Mol. weight
- 776.87 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
- Availability
- Prescription Only
Oral
Yes
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL559 ↗
- WikipediaDextrothyroxine ↗
- ChEMBLCHEMBL3545058 ↗
- NCATSYW8HJ0N26X ↗
- NCATS4W9K63FION ↗
Also known as
- dextrothyroxine
- dextrothyroxine
- dextrothyroxine
- dextrothyroxine
- dextrothyroxine
- dextrothyroxine
- dextrothyroxine
- dextrothyroxine
- dextrothyroxine sodium
- dextrothyroxine sodium
- dextrothyroxine sodium
- dextrothyroxine sodium
- dextrothyroxine sodium
- d-t4
- d-t4
- d-thyroxine
- d-thyroxine
- d-thyroxine
- sodium dextrothyroxine
- sodium dextrothyroxine
- sodium dextrothyroxine
- sodium dextrothyroxine
- sodium dextrothyroxine
- sodium dextrothyroxine
- t4 (liotrix)
- t4 (liotrix)
- thyroxine
- thyroxine
- thyroxine
- thyroxine
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02086799 | N/A | Jul 1, 2014 | Technion University |
| NCT02319538 | N/A | Feb 1, 2012 | Telemark Hospital Trust, University of Bergen |
| NCT02509858 | N/A | Feb 1, 2009 | University of Athens |
| NCT00565890 | N/A | Dec 1, 2005 | Tokyo Metropolitan Bokuto Hospital, Tokyo Women's Medical University |
| NCT01436994 | Phase 3 | Jul 1, 2004 | Newcastle University |
| NCT00360074 | Phase 4 | Feb 1, 2004 | University of Freiburg |
| NCT00111735 | Phase 4 | Apr 1, 2003 | University of Western Australia |
| NCT00715572 | N/A | Mar 1, 2002 | I.M. Sechenov First Moscow State Medical University, Moscow Medical Academy |
| NCT00000483 | N/A | Jun 1, 1981 | National Heart, Lung, and Blood Institute (NHLBI), University of Maryland |
| NCT00000482 | Phase 3 | Apr 1, 1965 | National Heart, Lung, and Blood Institute (NHLBI), University of Maryland |
Showing 10 of 10 trials
Page 1 / 1
Organizations
Research & Development (13)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Heart, Lung, and Blood Institute (NHLBI) | Government | 2 | 2 | 2 | 1965 |
| University of Maryland | Academic/Hospital | 2 | 0 | 2 | 1965 |
| I.M. Sechenov First Moscow State Medical University | Academic/Hospital | 1 | 1 | 1 | 2002 |
| Moscow Medical Academy | Academic/Hospital | 1 | 0 | 1 | 2002 |
| Newcastle University | Academic/Hospital | 1 | 1 | 1 | 2004 |
| Technion University | Academic/Hospital | 1 | 1 | 1 | 2014 |
| Telemark Hospital Trust | Academic/Hospital | 1 | 1 | 1 | 2012 |
| Tokyo Metropolitan Bokuto Hospital | Academic/Hospital | 1 | 0 | 1 | 2005 |
| Tokyo Women's Medical University | Academic/Hospital | 1 | 1 | 1 | 2005 |
| University of Athens | Academic/Hospital | 1 | 1 | 1 | 2009 |
| University of Bergen | Academic/Hospital | 1 | 0 | 1 | 2012 |
| University of Freiburg | Academic/Hospital | 1 | 1 | 1 | 2004 |
| University of Western Australia | Academic/Hospital | 1 | 1 | 1 | 2003 |
13 organizations
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