semuloparin
Small moleculeexperimental
Semuloparin is an experimental antithrombotic being developed by Sanofi-Aventis and belongs to the group of low molecular weight heparins (LMWH). It has completed Phase III clinical trials for the prevention of thromboembolism following various kinds of surgery such as hip replacement, as well as for patients undergoing chemotherapy. — Wikipedia
Clinical trial activity
10 trials · 9 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
10
Phase 3
8
Phase 4
0
Earliest trial started May 1, 2006 (NCT00331838)
Timeline
Indications
Mechanism of action
- Antithrombin-IIIINHIBITOR
SERPINC1 inhibitor
Indireclyt inhibits factor Xa (FXa) via binding to Antithrombin III.
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaSemuloparin sodium ↗
- ChEMBLCHEMBL2108718 ↗
Also known as
- ave5026
- ave 5026
- ave-5026
- ave-5026
- ave-5026
- semuloparin
- semuloparin
- semuloparin sodium
- semuloparin sodium
- s-lmwh
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02935530 | Phase 3 | Jan 1, 2016 | Huazhong University of Science and Technology |
| NCT01567904 | Phase 2 | May 1, 2012 | Sanofi |
| NCT00714597 | Phase 3 | Jul 1, 2008 | Jean Monnet University, McMaster University, Sanofi |
| NCT00718224 | Phase 3 | Jul 1, 2008 | Horsholm Hospital, Horsholm, Denmark, McMaster University, Sanofi |
| NCT00721760 | Phase 3 | Jul 1, 2008 | McGill University, McMaster University, Sanofi |
| NCT00694382 | Phase 3 | Jun 1, 2008 | McMaster University, Sanofi, University of Perugia |
| NCT00697099 | Phase 3 | Jun 1, 2008 | McMaster University, Sanofi |
| NCT00709904 | Phase 3 | Jun 1, 2008 | McGill University, McMaster University, Sanofi |
| NCT00679588 | Phase 3 | Apr 1, 2008 | Barts & The London NHS Trust, McMaster University, Sanofi |
| NCT00331838 | Phase 2 | May 1, 2006 | Hoersholm Hospital, Sanofi |
Showing 10 of 10 trials
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Organizations
Research & Development (9)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Sanofi | For profit | 9 | 9 | 2 | 2006 |
| McMaster University | Academic/Hospital | 7 | 0 | 1 | 2008 |
| McGill University | Academic/Hospital | 2 | 0 | 1 | 2008 |
| Barts & The London NHS Trust | Academic/Hospital | 1 | 0 | 1 | 2008 |
| Hoersholm Hospital | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Horsholm Hospital, Horsholm, Denmark | Academic/Hospital | 1 | 0 | 1 | 2008 |
| Huazhong University of Science and Technology | Academic/Hospital | 1 | 1 | 1 | 2016 |
| Jean Monnet University | Academic/Hospital | 1 | 0 | 1 | 2008 |
| University of Perugia | Academic/Hospital | 1 | 0 | 1 | 2008 |
9 organizations
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