antazoline

Trade name: vasocon-a

Small moleculeapproved

Approved

Apr 30, 1990

Antazoline is an antagonist of histamine H1 receptors. It selectively bind to but does not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Antazoline in combination with naphazoline (VASOCON-A®) is indicated to relieve the symptoms of allergic conjunctivitis. — NCATS

Clinical trial activity

2 trials · 2 clinical orgs · 1 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Earliest trial started Jan 1, 2009 (NCT01380678)

Timeline

1990s

Apr 30, 1990
Ciba-Geigy — Earliest FDA Approval
Apr 30, 1990
Ciba-Geigy — NDA Organization

2000s

Jan 1, 2009
Earliest Phase 3 Sponsor(trial)

Indications

Approved for

Conjunctivitis, Allergic (approved 1990)

Studied for

Mechanism of action

Histamine H1 receptorANTAGONIST
HRH1 antagonist
- Histamine H1 receptor (HRH1) ↗

Approval history

approvedApr 30, 1990

Chemistry & pharmacology

Loading structure…

SMILES

C(N(CC1=CC=CC=C1)C2=CC=CC=C2)C3=NCCN3

Mol. weight: 265.3529 g/mol
Lipinski Ro5: Pass
Rule of 3: No
Chirality: Achiral Molecule
Inorganic: No
Polymer: No
Delivery: Topical
Availability: Discontinued

Oral

Parenteral

Topical

Yes

Sources

Also known as

antaz hcl
antazoline
antazoline
antazoline
antazoline
antazoline
antazoline
antazoline
antazoline
antazoline
antazoline
antazoline
antazoline hcl
antazoline hcl
antazoline hcl
antazoline hydrochloride
antazoline hydrochloride
antazoline hydrochloride
antaz sulf
phenazoline
r.b.c.
vasocon-a
vasocon-a
vasocon-a

Clinical trials

NCT ID	Phase	Start date	Sponsor(s)
NCT01527279	Phase 4	Nov 1, 2012	Institute of Cardiology, Warsaw, Poland
NCT01380678	Phase 3	Jan 1, 2009	KhonKaen University

Showing 2 of 2 trials

Page 1 / 1

Organizations

Research & Development (2)

Organization	Org type	Trials	As lead sponsor	Phases	Earliest year
Institute of Cardiology, Warsaw, Poland	Academic/Hospital	1	1	1	2012
KhonKaen University	Academic/Hospital	1	1	1	2009

2 organizations

Page 1 / 1

Marketing (1)

Organization	Org type	Relationship	Date
Ciba-Geigy	For profit	NDA	Apr 30, 1990