sulfapyridine

Trade name: sulfapyridine

Small moleculeapproved

Approved

Mar 9, 1939

Sulfapyridine is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. It was used to treat of infections in humans in particular, dermatitis herpetiformis (Duhring's disease), a skin problem, but that usage was discontinued by manufacturer. It is also known, that sulfapyridine is one of the two primary metabolite of the anti-inflammatory drug salicylazosulfapyridine. — NCATS

Clinical trial activity

0 trials · 0 clinical orgs · 1 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Timeline

1930s

Mar 9, 1939
Eli Lilly — Earliest FDA Approval
Mar 9, 1939
Eli Lilly — NDA Organization

Indications

Approved for

Dermatitis Herpetiformis (approved 1939)

Mechanism of action

Bacterial dihydropteroate synthaseINHIBITOR
folP inhibitor
- Dihydropteroate synthase (folP) ↗

Approval history

approvedMar 9, 1939

Chemistry & pharmacology

Loading structure…

SMILES

NC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=N2

Mol. weight: 249.289 g/mol
Lipinski Ro5: Pass
Rule of 3: No
Chirality: Achiral Molecule
Inorganic: No
Polymer: No
Delivery: Oral
Availability: Discontinued

Oral

Yes

Parenteral

Topical

Sources

Also known as

concord 693
dagenan
dagenan
dagenan
eubasin
eubasin
n(1)-2-pyridylsulfanilamide
n(1)-pyridylsulfanilamide
n(1)-pyridylsulfanilamide
n-2-pyridylsulfanilamide
n-2-pyridylsulfanilamide
piridazol
piridazol
piridazol
pirodazole
plurazol
pyridazol
solfapiridina
solfapiridina
streptosilpyridine
streptosilpyridine
streptosilpyridine
sulfanilamidopyridine
sulfanilamidopyridine
sulfapiridina
sulfapiridina
sulfapyridin
sulfapyridin
sulfapyridine
sulfapyridine
sulfapyridine
sulfapyridine
sulfapyridine
sulfapyridine
sulfapyridine
sulfapyridine
sulfapyridine
sulfapyridine
sulfapyridine
sulfapyridinum
sulfapyridinum
sulfidin
sulfidine
sulphapyridine
sulphapyridine
sulphapyridine
sulphapyridine

Organizations

Marketing (1)

Organization	Org type	Relationship	Date
Eli Lilly	For profit	NDA	Mar 9, 1939