methylsulfonylmethane
Dimethyl sulfone (DMSO2) is an organosulfur compound with the formula (CH3)2SO2. It is also known by several other names including methyl sulfone and (especially in alternative medicine) methylsulfonylmethane (MSM). This colorless solid features the sulfonyl functional group and is the simplest of the sulfones. It is relatively inert chemically and is able to resist decomposition at elevated temperatures. It occurs naturally in some primitive plants, is present in small amounts in many foods and beverages, and is marketed (under the MSM name) as a dietary supplement. It is sometimes used as a cutting agent for illicitly manufactured methamphetamine. It is also commonly found in the atmosphere above marine areas, where it is used as a carbon source by the airborne bacteria Afipia. Oxidation of dimethyl sulfoxide produces the sulfone, both under laboratory conditions and metabolically. — Wikipedia
Clinical trial activity
6 trials · 9 clinical orgs · 0 marketing orgs
Earliest trial started Aug 21, 2010 (NCT01188213)
Timeline
Indications
Mechanism of action
- NF-kappaB inhibitor alphaINHIBITOR
NFKBIA inhibitor
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaMethylsulfonylmethane ↗
Also known as
- methane, sulfonylbis-
- methyl sulfone
- methyl sulfonmethane
- methylsulfonylmethane
- methylsulfonylmethane
- methylsulfonylmethane
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04664712 | N/A | Sep 11, 2019 | ASL Bari, University of Bari |
| NCT03747198 | N/A | Feb 1, 2019 | Bergstrom Nutrition, University of California, Davis |
| NCT03716791 | N/A | Jan 31, 2019 | Washington State University |
| NCT02268305 | Phase 3 | Feb 1, 2015 | United States Air Force |
| NCT01836757 | Phase 1 | Sep 1, 2012 | Aristotle University of Thessaloniki, G.Papanikolaou Research Group |
| NCT01188213 | N/A | Aug 21, 2010 | Tel Aviv University |
Organizations
Research & Development (9)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Aristotle University of Thessaloniki | Academic/Hospital | 1 | 0 | 1 | 2012 |
| ASL Bari | Academic/Hospital | 1 | 1 | 1 | 2019 |
| Bergstrom Nutrition | For profit | 1 | 0 | 1 | 2019 |
| G.Papanikolaou Research Group | Academic/Hospital | 1 | 1 | 1 | 2012 |
| Tel Aviv University | Academic/Hospital | 1 | 1 | 1 | 2010 |
| United States Air Force | Government | 1 | 1 | 1 | 2015 |
| University of Bari | Academic/Hospital | 1 | 0 | 1 | 2019 |
| University of California, Davis | Academic/Hospital | 1 | 1 | 1 | 2019 |
| Washington State University | Academic/Hospital | 1 | 1 | 1 | 2019 |