methylcatechol

Small moleculeexperimental

Guaiacol is a naturally occurring organic compound first isolated by Otto Unverdorben in 1826. Although it is biosynthesized by a variety of organisms, this yellowish aromatic oil is usually derived from guaiacum or wood creosote. Guaiacol is used as a reducing co-substrate for COX reactions. It is mainly used as expectorant, antiseptic. It is used as cough suppressant, it is an ingredient of Pulmo Bailly (UK). Pulmo Bailly Cough Expectorant is indicated for relief for cough symptoms that are associated with a flu, cold, or other infection. It contains active ingredients, Codeine and Guajacol, which reduce discomfort and the urge to cough. Each 5 ml tablespoon of Pulmo Bailly contains 75 mg guaiacol and 7 mg codeine. — NCATS

Clinical trial activity

2 trials · 2 clinical orgs · 0 marketing orgs

Phase 1
0
Phase 2
2
Phase 3
2
Phase 4
0

Earliest trial started May 1, 2011 (NCT01119534)

Timeline

2010s

  1. Jan 1, 2011

    Earliest Phase 3 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

  • Unspecified targetUnclear

    unclear

Chemistry & pharmacology

Loading structure…

SMILES

COC1=CC=CC=C1O
Mol. weight
124.1372 g/mol
Lipinski Ro5
Pass
Rule of 3
Yes
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • 1-hydroxy-2-methoxybenzene
  • 1-hydroxy-2-methoxybenzene
  • 2-methoxyl-4-vinylphenol
  • 2-methoxyl-4-vinylphenol
  • 2-methoxyphenol
  • 2-methoxyphenol
  • 2-methoxyphenol
  • guaiacol
  • guaiacol
  • guaiacol
  • guaiacol
  • guaiacol
  • guaiacol
  • guaiacol
  • guaiacol
  • guaiacol
  • guaiastil
  • methylcatechol
  • o-guaiacol
  • o-guaiacol
  • o-hydroxyanisole
  • o-hydroxyanisole
  • o-methoxyphenol
  • o-methoxyphenol
  • pyrocatechol monomethyl ether
  • pyrocatechol monomethyl ether
  • pyroguaiac acid
  • pyroguaiac acid

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT02581397Phase 3May 1, 2015Ache Laboratorios Farmaceuticos S.A.
NCT01119534Phase 3May 1, 2011Azidus
Showing 2 of 2 trials
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Organizations

Research & Development (2)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Ache Laboratorios Farmaceuticos S.A.For profit1112015
AzidusFor profit1112011
2 organizations
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