methylcatechol
Guaiacol is a naturally occurring organic compound first isolated by Otto Unverdorben in 1826. Although it is biosynthesized by a variety of organisms, this yellowish aromatic oil is usually derived from guaiacum or wood creosote. Guaiacol is used as a reducing co-substrate for COX reactions. It is mainly used as expectorant, antiseptic. It is used as cough suppressant, it is an ingredient of Pulmo Bailly (UK). Pulmo Bailly Cough Expectorant is indicated for relief for cough symptoms that are associated with a flu, cold, or other infection. It contains active ingredients, Codeine and Guajacol, which reduce discomfort and the urge to cough. Each 5 ml tablespoon of Pulmo Bailly contains 75 mg guaiacol and 7 mg codeine. — NCATS
Clinical trial activity
2 trials · 2 clinical orgs · 0 marketing orgs
Earliest trial started May 1, 2011 (NCT01119534)
Timeline
2010s
- Jan 1, 2011
Earliest Phase 3 Sponsor(trial)
Indications
Approved for
Studied for
Mechanism of action
- Unspecified targetUnclear
unclear
Chemistry & pharmacology
SMILES
COC1=CC=CC=C1O- Mol. weight
- 124.1372 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaMethylcatechol ↗
- NCATS6JKA7MAH9C ↗
- ChEMBLCHEMBL13766 ↗
Also known as
- 1-hydroxy-2-methoxybenzene
- 1-hydroxy-2-methoxybenzene
- 2-methoxyl-4-vinylphenol
- 2-methoxyl-4-vinylphenol
- 2-methoxyphenol
- 2-methoxyphenol
- 2-methoxyphenol
- guaiacol
- guaiacol
- guaiacol
- guaiacol
- guaiacol
- guaiacol
- guaiacol
- guaiacol
- guaiacol
- guaiastil
- methylcatechol
- o-guaiacol
- o-guaiacol
- o-hydroxyanisole
- o-hydroxyanisole
- o-methoxyphenol
- o-methoxyphenol
- pyrocatechol monomethyl ether
- pyrocatechol monomethyl ether
- pyroguaiac acid
- pyroguaiac acid
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02581397 | Phase 3 | May 1, 2015 | Ache Laboratorios Farmaceuticos S.A. |
| NCT01119534 | Phase 3 | May 1, 2011 | Azidus |
Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Ache Laboratorios Farmaceuticos S.A. | For profit | 1 | 1 | 1 | 2015 |
| Azidus | For profit | 1 | 1 | 1 | 2011 |