deslanoside
Trade name: cedilanid
Small moleculeapproved
Approved
Jun 1, 1956
Deslanoside is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia. It is found in the leaves of Digitalis lanata, the Woolly Foxglove. — Wikipedia
Clinical trial activity
0 trials · 0 clinical orgs · 1 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Timeline
1950s
- Jun 1, 1956
Earliest FDA Approval
Indications
Approved for
Mechanism of action
HCN1 antagonist
- Sodium/potassium-transporting ATPaseINHIBITOR
Sodium/potassium-transporting ATPase inhibitor
May also have antiviral and anticancer effects mediated by alternative mechanisms (PMID: 32784680)
Alpha subunit
- Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) ↗
- Sodium/potassium-transporting ATPase subunit beta-2 (ATP1B2) ↗
- Sodium/potassium-transporting ATPase subunit beta-1 (ATP1B1) ↗
- Sodium/potassium-transporting ATPase subunit alpha-2 (ATP1A2) ↗
- Sodium/potassium-transporting ATPase subunit beta-3 (ATP1B3) ↗
- Sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3) ↗
- Sodium/potassium-transporting ATPase subunit alpha-4 (ATP1A4) ↗
- Sodium/potassium-transporting ATPase subunit gamma (FXYD2) ↗
- Sodium/potassium-transporting ATPase alpha-1 chain
- Sodium/potassium-transporting ATPase beta-3 chain
- Sodium/potassium-transporting ATPase subunit alpha-2/beta-1
- Sodium/potassium-transporting ATPase subunit alpha-1/beta-1
- Sodium/potassium-transporting ATPase subunit alpha-2/beta-3
- Sodium/potassium-transporting ATPase subunit alpha-2/beta-2
- Sodium/potassium-transporting ATPase beta-1 chain
Approval history
- approvedJun 1, 1956
Chemistry & pharmacology
Loading structure…
SMILES
CC(=O)O[C@H]1C[C@H](O[C@H]2[C@@H](O)C[C@H](O[C@H]3[C@@H](O)C[C@H](O[C@H]4CC[C@@]5(C)[C@H](CC[C@@H]6[C@@H]5C[C@@H](O)[C@]5(C)[C@@H](C7=CC(=O)OC7)CC[C@]65O)C4)O[C@@H]3C)O[C@@H]2C)O[C@H](C)[C@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O- Mol. weight
- 985.13 g/mol
- Lipinski Ro5
- 3 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaDeslanoside ↗
- ChEMBLCHEMBL506569 ↗
Also known as
- 3-((o beta-d-glucopyranosyl-(1-4)-o-3 beta-o-acetyl- 2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1-4)-o-2,6- dideoxy-beta-d-ribo-hexopyranosyl-(1-4)-o-2,6- dideoxy-beta-d-ribo-hexopyranosyl)oxy)-12 beta,14-dihydroxy-5 beta-card-20(22)-enolide
- allocor
- allocor
- cedilanid
- cedilanid
- cedilanid
- cedilanid
- cedilanid
- ceglunat
- ceglunat
- ceglunate
- celadigal
- celanid
- celanide
- celanide
- cetosanol
- digilanide c
- digilanogen c
- isolanid
- isolanid
- isolanide
- lanatigen c
- lanatigen c
- lanatoside c
- lanatoside c
- lanatoside c
- lanatoside c
- lanatoside c
- lanatoside c
- lanocide
Organizations
Marketing (1)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Sandoz | For profit | NDA | — |