cyclothiazide
Trade name: anhydron
Small moleculeapproved
Approved
Aug 20, 1963
Cyclothiazide was presumably developed by Eli Lilly for the treatment of hypertension. It is believed that the drug, which belongs to the class of thiazide diuretics, exerts its action by inhibitin sodium reabsorption in the renal tubules. In 1993 it was discovered that cyclothiazide stimulates AMPA receptors thus inducing seizure behavior. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 2 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Timeline
1980s
- Jun 8, 1982
Pharmacia & Upjohn — NDA Secondary Org
Indications
Approved for
Mechanism of action
SLC12A3 inhibitor
Approval history
- approvedAug 20, 1963
Chemistry & pharmacology
Loading structure…
SMILES
NS(=O)(=O)C1=C(Cl)C=C2NC(NS(=O)(=O)C2=C1)C3CC4CC3C=C4- Mol. weight
- 389.878 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
- Availability
- Discontinued
Oral
Yes
Parenteral
No
Topical
No
Sources
- WikipediaCyclothiazide ↗
- NCATSP71U09G5BW ↗
- ChEMBLCHEMBL61593 ↗
Also known as
- 35483
- 6-chloro-3-(2-norbornen-5-yl)-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
- 6-chloro-3-(2-norbornen-5-yl)-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
- 6-chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
- 6-chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
- 6-chloro-3,4-dihydro-3-(2-norbornen-5-yl)-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide
- 6-chloro-3,4-dihydro-3-(2-norbornen-5-yl)-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide
- 6-chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
- 6-chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
- anhydron
- anhydron
- anhydron
- ciclotiazida
- ciclotiazida
- ciclotiazide
- ciclotiazide
- ciclotiazide
- cyclothiazide
- cyclothiazide
- cyclothiazide
- cyclothiazide
- cyclothiazide
- cyclothiazide
- cyclothiazide
- cyclothiazide
- cyclothiazide
- cyclothiazidum
- cyclothiazidum
- fluidil
- fluidil
Organizations
Marketing (2)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Eli Lilly | For profit | NDA | Aug 20, 1963 |
| Pharmacia & Upjohn | For profit | NDA2 | Jun 8, 1982 |