spiramycin

Small moleculeexperimental

Clinical trial activity

4 trials · 4 clinical orgs · 0 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Earliest trial started Nov 2, 1999 (NCT00002062)

Timeline

1990s

Jan 1, 1999
Earliest Phase 1 Sponsor(trial)

2010s

Jan 1, 2010
Earliest Phase 3 Sponsor(trial)

Indications

Approved for

Bacterial Infections

Studied for

Mechanism of action

50S ribosomal protein L2INHIBITOR
rplB inhibitor
- 50S ribosomal protein L2 (rplB) ↗
Bacterial 70S ribosomeINHIBITOR
Bacterial 70S ribosome inhibitor
50S, 23S RNA

Chemistry & pharmacology

Loading structure…

SMILES

CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1O

Mol. weight: 843.06 g/mol
Lipinski Ro5: 2 violation(s)
Rule of 3: No
Chirality: Single Stereoisomer
Inorganic: No
Polymer: No

Oral

Parenteral

Topical

Sources

Also known as

acetylspiramycin
acetylspiramycin
acetylspiramycin
acetylspiramycin
demycarosylturimycin h
demycarosylturimycin h
espiramicin
foromacidin
foromacidin a
foromacidin a
foromacidin b
foromacidin b
foromacidin c
foromacidine a
foromacidine a
foromacidine a
foromacidine b
foromacidine c
il-5902
il-5902
leucomycin v
provamycin
rovamicina
rovamycin
rovamycin
rovamycin
rovamycine
rovamycine
rovamycine
rovamycine 250
rp-5337
rp-5337
selectomycin
sequamycin
spiramycin
spiramycin
spiramycin
spiramycin
spiramycin
spiramycin
spiramycin
spiramycin
spiramycin 1
spiramycin 1
spiramycin 2
spiramycin 3
spiramycin a
spiramycin a
spiramycin b
spiramycin c
spiramycin c
spiramycin i
spiramycin i
spiramycin i
spiramycin ii
spiramycin ii
spiramycin ii
spiramycin ii
spiramycin ii
spiramycin iii
spiramycin iii
spiramycins
stomamycin

Clinical trials

NCT ID	Phase	Start date	Sponsor(s)
NCT01189448	Phase 3	Nov 1, 2010	University of Paris
NCT00004317	Phase 4	Jul 1, 2000	National Institute of Allergy and Infectious Diseases (NIAID), University of Chicago
NCT00000980	Phase 1	Nov 2, 1999	National Institute of Allergy and Infectious Diseases (NIAID), Rhone-Poulenc Rorer
NCT00002062	N/A	Nov 2, 1999	Rhone-Poulenc Rorer

Showing 4 of 4 trials

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Organizations

Research & Development (4)

Organization	Org type	Trials	As lead sponsor	Phases	Earliest year
National Institute of Allergy and Infectious Diseases (NIAID)	Government	2	1	2	1999
Rhone-Poulenc Rorer	For profit	2	2	2	1999
University of Chicago	Academic/Hospital	1	0	1	2000
University of Paris	Academic/Hospital	1	1	1	2010

4 organizations

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