tolnaftate
Small moleculeexperimental
Tolnaftate is a thiocarbamate derivative used as an over-the-counter anti-fungal agent for treatment of athlete's foot and ringworm. Tolnaftate acts by inhibition of ergosterol biosynthesis pathway in fungal cells. — NCATS
Clinical trial activity
1 trials · 2 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
1
Phase 3
1
Phase 4
0
Earliest trial started May 1, 2012 (NCT01429701)
Timeline
2010s
- Jan 1, 2012
Earliest Phase 3 Sponsor(trial)
Indications
Approved for
Studied for
Mechanism of action
- Unspecified targetUnclear
unclear
Chemistry & pharmacology
Loading structure…
SMILES
CN(C(=S)OC1=CC=C2C=CC=CC2=C1)C3=CC=CC(C)=C3- Mol. weight
- 307.409 g/mol
- Lipinski Ro5
- 3 violation(s)
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaTolnaftate ↗
- NCATS06KB629TKV ↗
- ChEMBLCHEMBL83668 ↗
- ChEMBLCHEMBL229383 ↗
Also known as
- 2-naphthyl n-methyl-n-(3-tolyl)thionocarbamate
- 2-naphthyl n-methyl-n-(3-tolyl)thionocarbamate
- aftate
- aftate
- dr. scholl's athlete's foot spray
- dr. scholl's athlete's foot spray
- methyl (3-methylphenyl)carbamothioic acid o-2-naphthalenyl ester
- methyl (3-methylphenyl)carbamothioic acid o-2-naphthalenyl ester
- m,n-dimethylthiocarbanilic acid o-2-naphthyl ester
- m,n-dimethylthiocarbanilic acid o-2-naphthyl ester
- mycil
- mycil
- n-methyl-n-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamide
- n-methyl-n-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamide
- o-2-naphthyl m,n-dimethylthiocarbanilate
- o-2-naphthyl m,n-dimethylthiocarbanilate
- sch-10144
- sch-10144
- separin
- separin
- timoped
- timoped
- tinactin
- tinactin
- tinaderm
- tinaderm
- tinaderm m
- tinaderm plus
- tolnaftate
- tolnaftate
- tolnaftate
- tolnaftate
- tolnaftate
- tolnaftate
- tolnaftate
- tolnaftate
- tolnaftato
- tolnaftato
- tolnaftato
- tolnaftatum
- tolnaftatum
- tolnaphthate
- tolnaphthate
- tolnaphthate
- tolsanil
- tonoftal
- tritin
- tritin
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01429701 | Phase 3 | May 1, 2012 | EMS S/A, Medicin Instituto da Pele |
Showing 1 of 1 trials
Page 1 / 1
Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| EMS S/A | For profit | 1 | 1 | 1 | 2012 |
| Medicin Instituto da Pele | Academic/Hospital | 1 | 0 | 1 | 2012 |
2 organizations
Page 1 / 1