dihydroergocryptine mesylate
Small moleculeexperimental
Dihydro-alpha-ergocryptine is an ergot alkaloid that has an agonist activity on D2 dopaminergic receptors and a partial agonist activity on D1 receptors. It also demonstrated antagonistic activity towards alpha-adrenergic receptors. The drug was approved by FDA in combination with other alkaloids (dihydroergocornine, dihydroergocristine and dihydro-beta-ergocryptine mesylate salts) under the name Hydergine for the treatment of dimentia and cerebrovascular insufficiency. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Indications
Chemistry & pharmacology
Loading structure…
SMILES
CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12- Mol. weight
- 577.73 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL1743263 ↗
- WikipediaDihydroergocryptine ↗
- NCATS202229IR8Y ↗
- ChEMBLCHEMBL3707289 ↗
Also known as
- dihydro-.alpha.-ergocryptine
- dihydro-.alpha.-ergocryptine
- dihydro-.alpha.-ergocryptine
- dihydro-.alpha.-ergocryptine
- dihydro-.alpha.-ergocryptine
- dihydro-.alpha.-ergocryptine mesilate
- dihydro-.alpha.-ergocryptine mesylate
- dihydroergocriptine
- dihydroergocryptine mesilate
- dihydroergocryptine mesylate
- dihydroergocryptine mesylate
- dihydroergocryptine mesylate